“I have researched the anti-cellulite action of different nutrients for the last 25+ years and pterostilbene is one of my favourites, as it has a multi-prong action against cellulite. This study, for example, has shown that pterostilbene inhibits fat accumulation in four different ways () and can therefore have a positive contribution in the fight against overweight, obesity and also cellulite”
Pterostilbene vs cellulite
Pterostilbene, resveratrol, berries, fat accumulation and obesity
Pterostilbene and fat cells
Pterostilbene against obesity and cellulite
Pterostilbene in fruits, supplements and anti-ageing / anti-cellulite creams
Antiadipogenic and antiobesogenic effects of pterostilbene in 3T3-L1 preadipocyte models
LipoTherapeia® Plus: Have a skin tightening/cellulite treatment with London’s cellulite experts
The Cellulite School™: Get advanced training in cellulite reduction and skin tightening
Pterostilbene, resveratrol, berries, fat accumulation and obesity
Obesity, a metabolic disease characterised by excessive accumulation of fat in the body, is closely related to many diseases such as cancer, diabetes, cardiovascular, dyslipidemia, hypertension, sleep apnea and overall ageing. As a result, obesity has become a global public health problem and there is a constant search for natural compounds to prevent or reduce obesity.
Adipogenesis, i.e. the growth of new fat cells, is accompanied by fat accumulation and consequent adipocyte hypertrophy (fat cell enlargement).
Pterostilbene, a small molecular weight stilbenoid compound chemically related to resveratrol and found predominantly in black grapes, blueberries and other berries, has important anti-adipogenic, antioxidant, anti-inflammatory, anti-diabetic and anticancer properties.
Resveratrol is already widely known for its anti-ageing and anti-obesity properties and pterostilbene (3',5'-dimethoxy-resveratrol), being a more stable and more absorbable form of resveratrol, shows even more promise in fighting against both ageing and fat accumulation.
Pterostilbene and fat cells
In the study below, pterostilbene was found to have the following effects in adipocytes (fat cells):
Pterostilbene inhibits adipocyte proliferation and growth (in simple terms, with pterostilbene fat cells stop growing both in numbers and in size)
Pterostilbene reduces adipocyte lipid accumulation (in simple terms, with pterostilbene fat cells do not accumulate fat inside them)
Pterostilbene, at high concentrations, induces apoptosis in differentiated 3T3-L1 adipocytes (in simple terms, with pterostilbene mature fat cells die off)
Pterostilbene preserves fibroblastic morphology in preadipocytes (in simple terms, with pterostilbene baby fat cells grow into a collagen cell form rather than into a full-blown fat cell form)
According to the study authors, “All our results show that PTS can be considered to have a significant role in the treatment and prevention of obesity by reducing the differentiation of preadipocytes with its anti-adipogenic and anti-obesogenic effect”.
Pterostilbene against obesity and cellulite
Based on the above data, pterostilbene shows great promise both against overweight and obesity.
Given that runaway lipid accumulation, adipocyte proliferation and adipocyte growth in the deeper skin layer (hypodermis) are hallmarks of cellulite, it is obvious that pterostilbene is an important anti-cellulite molecule.
Hence our constant recommendation on this website to consume a high amount of berry fruits, as well as vegetable and oily fish, and in addition to exercising and avoiding sugar and fried food, in order to prevent and reduce cellulite.
Pterostilbene in fruits, supplements and anti-ageing / anti-cellulite creams
As mentioned above, pterostilbene is primarily found in berry fruits, grapes and grape vine leaves. Based on the type of blueberry ingested, the content of pterostilbene is estimated to range from 25mg to 130mg per 250 gram of fruit serving.
Pterostilbene is also available in supplement form, at doses from 25-500mg per capsule. If we assume 100mg/400g of blueberries is the average, it makes much more sense to eat 400g of blueberries, which also contain fibre and multiple other polyphenols / antioxidants, than consume 100mg pterostilbene capsules.
Due to its small size below 500 Dalton, pterostilbene is an ideal ingredient in anti-cellulite and anti-ageing formulations. However, at the moment there is no known cream currently available that contains any significant amount of pterostilbene.
Antiadipogenic and antiobesogenic effects of pterostilbene in 3T3-L1 preadipocyte models
Research paper link: https://pubmed.ncbi.nlm.nih.gov/37529167
Abstract: Since obesity causes at least 2.8 million death each year and is a major risk factor for many diseases, it is critical to evaluate alternative treatment approaches. In this context, studies on the research of natural product-based therapeutics in the fight against obesity are increasing. In this study, it was aimed to evaluate the antiadipogenic and antiobesogenic efficacy of pterostilbene a natural phenolic compound in 3T3-L1 cells. The mature 3T3-L1 adipocytes were exposed to pterostilbene at different concentrations and half-maximum inhibitory concentrations (IC50) were determined by MTT assay. Oil-Red-O staining was applied to determine lipid accumulation. Phase contrast microscopy, Giemsa, F-actin and DAPI staining were applied to examine the efficacy of pterostilbene on the morphology of 3T3-L1 adipocyte cells. Moreover, expressions of adinopectin and glucose transporter-4 (Glut-4) in relation to insulin resistance were evaluated using immunofluorescent staining and qRT-PCR. Pterostilbene caused no significant cytotoxicity towards preadipocytes at concentrations ≤7.5 -M and the percentage of viable cells remained above about 86% for 24 h, 48 h and 72 h (p > 0.05). Therefore, pterostilbene treatment at 5 and 7.5 -M was used in the subsequent experiments as safe dosages. In addition, it was observed that pterostilbene treatment reduced lipid accumulation in adipocyte differentiation. Adipocytes treated with a dose of 7.5 -M for 14 days showed less intense lipid deposition and a more spindle-like morphology compared to the adipocytes treated with a dose of 5 -M. Especially on the 14th day, actin filaments were filamentous in adipocytes treated with pterostilbene 7.5 -M compared to the adipocytes treated with a dose of 5 -M; the filaments were similarly oriented as in preadipocytes, and chromatin condensation was observed to be quite high. Our data suggests that the pterostilbene supplementation may help weight control and the antiadipogenic and that antiobesogenic activity is mediated in part by reduction of lipid accumulation and induction of Glut-4 and Adiponectin levels.
LipoTherapeia® Plus: Have a skin tightening/cellulite treatment with London’s cellulite experts
At LipoTherapeia we have specialised 100% in skin tightening and cellulite reduction for more than a quarter of a century and 24,000+ sessions.
This is all we study and practise every day and have researched and tried hands-on all the important skin tightening equipment and their manufacturers.
As strong, deep acting radiofrequency and deep-acting, high-power ultrasound cavitation are the technologies of choice for skin tightening and cellulite reduction, we have invested in the best RF/ultrasound technologies in the world.
(Of course, we keep looking for new technologies every day and if/when a better technology materialises we will be the first to provide it. However, we will never follow the latest ineffective gimmick, just because it’s good marketing to offer the latest hyped up - yet ineffective and/or unsafe treatment.)
Furthermore, over the last two decades we have developed advanced RF and cavitation treatment protocols in order to make the most of our technologies, for maximum results, naturally and safely.
And for even better, faster results, we now combine our RF/ultrasound treatments with high-power red/infrared light LED treatment.
Our radiofrequency/ultrasound/LED treatments are comfortable, pain-free, downtime-free, injection-free, 99.5%+ safe and always non-invasive.
(No unsafe and ineffective RF microneedling or HIFU and no safe but ineffective acoustic wave therapy, superficial RF (bipolar/tripolar/multipolar etc), low power RF/cavitation, electrical muscle stimulation, lymphatic massage, cupping, dry brushing and no ridiculous bum bum creams.)
Our focus is on honest, realistic, science-based treatment, combined with caring, professional service, with a smile.
We will be pleased to see you, assess your cellulite, skin laxity or fibrosis, listen to your story, discuss your case and offer you the best possible treatment.
Check prices and book an expert cellulite / skin tightening treatment at our London clinic.
Look Inside Your Skin™ with a Cellulite Ultrasonography™ scan, exclusive to LipoTherapeia in London, and assess your cellulite, skin laxity, post-liposuction fibrosis and more
We are proud to be the first and only cellulite clinic in the world to offer Cellulite Ultrasonography™ to our clients, for accurate assessment, better treatment and enhanced results. Since 2022 we have assessed and provided valuable insights to hundreds of clients to better understand their specific case, see how their skin looks from inside and make informed decisions.
You can now book your Cellulite Ultrasonography™ session and assess your:
Cellulite
Skin laxity
Lipedema
Subcutaneous fat levels
You can also assess the presence and severity of fibrosis and adhesions after:
Liposuction in all its forms, including vaser, smart lipo, bodytite, abdominoplasty/tummy tuck, thigh lift, arm lift, lipedema surgery etc
Cellulite surgery, such as cellulaze, cellutite, cellfina, subcision etc
Face-lift surgery
Non-surgical procedures, such as RF microneedling, extreme intensity HIFU, extreme intensity RF, extreme intensity ultrasound etc
Everything will be shown and explained to you clearly and you can see and understand how the different structures inside your skin affect your appearance.
If there is scar tissue / fibrosis, those will be clearly seen and you can differentiate between fibrosis, water retention or unremoved fat after all types of cosmetic surgery or harsh non-surgical procedures such as RF microneedling, extreme intensity HIFU etc.
(DISCLAIMER: Please note that this service is for your informational purposes only and does not constitute medical diagnosis or advice.)
The 45’ appointment includes full assessment and consultation and optional treatment plan for cellulite reduction and/or skin tightening.
If you do wish to have treatment with us, the ultrasound scan, assessment and consultation will be used to optimise your course of treatments and maximise your results.
The Cellulite School™: Get advanced training in cellulite reduction and skin tightening
Why train with The Cellulite School™?
We all know that training in cellulite reduction and skin tightening is as basic as it gets. It is typically a 4-6 hour training, involving only basic instruction from the manufacturer on how operators can use the machine; lots of myths, erroneous information and misconceptions; and some basic health and safety on how to use the machine.
There is no proper, real training in the science or cellulite, skin tightening, radiofrequency, ultrasound and all related technologies is non-existent - worldwide.
Do you want to deeply understand radiofrequency, ultrasound cavitation, LED phototherapy, cellulite and skin tightening?
Get proper training based on 25-year theory and practical application of cellulite reduction and valuable insights from 24,000+ sessions and 4,200+ clients.
Now you can get instant access to our expertise and save yourself literally thousands of pounds, dollars or euros of expensive mistakes and thousands of hours of study, research and practical application by attending one of our half-day, 1-day, 2-day or 3-day professional consultancy / training courses.
Understand deeply - and get properly trained in - the science of radiofrequency, ultrasound cavitation, LED phototherapy, cellulite and skin tightening and confidently offer your clients the safest, strongest and most effective treatment possible.
Service available via Zoom or at our central London practice.
Learn more or check prices and book training at our London clinic or via Zoom.