Carnosine and your skin
glycation, antioxidant, anti-ageing, cellulite
Carnosine is one of the most important and most widely used anti-ageing actives. It is widely researched for it's action against glycation. Glycation is the main cause of collagen damage (caused by sugar consumption) and thereby skin ageing, blood vessel wall damage and also a major contributor to the formation of cellulite.
For all those reasons, carnosine is of great importance as active ingredient in anti-ageing, anti-cellulite, leg wellness, skin firming and under-eye creams [the Celluence® cellulite creams are the only creams in the world to contain pure, highly bioavailable carnosine PLUS 39 more natural actives, for maximum results with cellulite and skin tightening].
4+ ways Carnosine
helps fight glycation, free radical damage and overall ageing
Antiglycation and anti-oxidant efficiency of carnosine in the plasma and liver of aged rats.
Abstract: AIM: Increases in oxidative stress and advanced glycation end-products (AGE) formation play an important role in the pathogenesis of aging. Carnosine (CAR; β-alanyl-L-histidine) has anti-oxidant and antiglycating properties. We investigated the effect of CAR supplementation on AGE levels, and protein and lipid oxidation products in the serum and liver tissue in aged rats. METHODS: Young (3 months-of-age) and aged (20 months-of-age) rats were injected with CAR (250 mg/kg/daily; i.p.; 5 days per week) for 2 months. At the end of this period, AGE, protein carbonyl, advanced oxidized protein products, and malondialdehyde levels were determined in the serum and liver tissue. Furthermore, reactive oxygen species formation and ferric reducing anti-oxidant power values were measured. RESULTS: AGE, malondialdehyde, protein carbonyl and advanced oxidized protein products levels, and reactive oxygen species formation were higher in the serum and liver tissue of aged rats compared with young rats. CAR treatment was observed to significantly decrease AGE, malondialdehyde, protein carbonyl and advanced oxidized protein products levels, and reactive oxygen species formation in the serum and liver of aged rats. CONCLUSIONS:
These results clearly show that CAR might be useful for decreasing glycoxidant stress in aged rats