“We have been saying for more than 15 years now that Advanced Glycation End-products (AGE) are a major cause of skin ageing, overall body ageing and indeed cellulite and it seems most people - including so-called experts in the aesthetics industry - are quite unaware of their importance. However, the facts are the facts and thousands of studies have shown that AGEs are major contributors to inflammation, free radical damage, collagen deterioration on skin and blood vessels, which all translates into ageing and cellulite. Read more below…”
Frying, toasting, high-temperature grilling, charring, smoking and burning of food all lead to disease, skin ageing and cellulite
Advanced Glycation End-products (AGE) from high temperature cooking cause ageing and cellulite
Senescence, whole body aging, skin ageing and cellulite
Charring and smoking of food and cellulite
Senolytic food ingredients, supplements and skincare ingredients
Fisetin is found in:
Quercetin is found in:
EGCG is found in:
Curcumin is found in:
Glyoxal induces senescence in human keratinocytes through oxidative stress and activation of the AKT/FOXO3a/p27 KIP1 pathway
LipoTherapeia® Plus: Have a skin tightening/cellulite treatment with London’s cellulite experts
The Cellulite School™: Get advanced training in cellulite reduction and skin tightening
Advanced Glycation End products (AGE), whole body aging, skin aging and cellulite
It is now well known to science (thousands of research papers) that cigarette smoking, food smoking and high temperature cooking of carbohydrates and fats, all lead to the creation of various chemicals detrimental to health, two of them being glyoxal and methylglyoxal (MGO).
These chemicals eventually lead to the creation of Advanced Glycation End-products (AGEs), which are proven to cause whole body ageing, skin ageing and cellulite.
Senescence, whole body aging, skin ageing and cellulite
However, glyoxal/MGO on their own are also detrimental to health and appearance - not just because they cause AGE formation.
This new study below shows that glyoxal and methylglyoxal cause senescence on epidermal skin cells (keratinocytes), regardless of glycation and formation of AGEs.
Senescence itself is a major cause of whole body aging and skin ageing. It is basically the transformation of healthy cells into permanently aged ones that literally spread inflammation throughout the body.
Senescence is known to affect adipose tissue, causing dysfunction and inflammation. It wouldn’t be a wild guess to state that senescence is a major cause of cellulite.
Anti-senescent / senolytic natural molecules (see below) may be able to halt this progression, but healthy eating will actually prevent it from happening in the first place:
Avoid smoking and frying, toasting, high-temperature grilling, charring and smoking of food
Avoid excessive sugar/carb consumption
Charring and smoking of food and cellulite
Charring and smoking food, specifically, is very trendy these days, e.g. charred pork fat, charred cabbage, charred cauliflower to resemble a “steak”, smoking when barbecuing etc.
Quite often you see on instagram steaks first being fried to “seal them” and then both charred and smoked in a closed BBQ smoker and then fried with butter. Is there ANYTHING more unhealthy in this world?
Those “chefs” that promote burning the food should know better. These cooking methods cause not just cancer and cardiovascular disease (something which everyone knows these days), but also senescence and glycation, leading to whole body ageing, skin ageing and, yes, cellulite.
Chefs, especially famous chefs, have a responsibility to provide and promote nutritious food, not horrible junk to their customers. And heat-damaged food easily qualifies as nutritional junk.
To reduce the burden of AGEs and glyoxal/methylglyoxal, you can also consume the following anti-senescence natural molecules, in addition to eating not burned / not smoked / not fried food.
Senolytic food ingredients, supplements and skincare ingredients
The most effective known senolytic (anti-senescent) natural molecules are, in order of importance:
Fisetin
Quercetin
EGCG
Curcumin
Fisetin is found in:
Small amounts in foods (berries)
Small to sufficient amounts in supplements
Tiny (=useless) amounts in a very small number of skincare products
Quercetin is found in:
Decent amounts in foods (red onions, buckwheat, citrus and berry fruits)
Medium to high amounts in supplements
Tiny amounts in a small number of skincare products, as it is too orange to be included in meaningful amounts in skincare
EGCG is found in:
In medium to high amounts in any type of green tea (any kind, no need for overpriced matcha)
Medium to high amounts in supplements
Meaningful amounts in a very small number of skincare products
Curcumin is found in:
Medium amounts in turmeric
Medium to high amounts in supplements
Meaningful amounts in a very small number of skincare products
Glyoxal induces senescence in human keratinocytes through oxidative stress and activation of the AKT/FOXO3a/p27 KIP1 pathway
Research paper link: https://pubmed.ncbi.nlm.nih.gov/34971698
Abstract: Glyoxal induces senescence in human keratinocytes through oxidative stress and activation of the Senescence is a well-characterized cellular state associated with specific markers such as permanent cell proliferation arrest, and the secretion of messenger molecules by cells expressing the Senescence-Associated Secretory Phenotype (SASP). The SASP composition depends on many factors such as the cell type or the nature of the stress that induces senescence. Since the skin constitutes a barrier with the external environment, it is particularly subjected to different types of stresses, and consequently prone to premature cellular aging. The dicarbonyl compounds glyoxal and methylglyoxal are precursors of Advanced Glycation End-products (AGEs), whose presence marks normal and pathological aging. In this study, we demonstrate that glyoxal treatment provokes oxidative stress by increasing reactive oxygen species and AGEs levels and induces senescence in human keratinocytes. Furthermore, glyoxal-induced senescence bears a unique molecular progression profile: an "early-stage" when AKT-FOXO3a-p27KIP1 pathway mediates cell-cycle arrest, and a "late-stage" senescence maintained by the p16INK4/pRb pathway. Moreover, we characterized the resulting secretory phenotype during early senescence by mass spectrometry. Our study provides evidence that glyoxal can affect keratinocyte functions and act as a driver of human skin aging. Hence, senotherapeutics aimed at modulating glyoxal-associated senescence phenotype hold promising potential.
LipoTherapeia® Plus: Have a skin tightening/cellulite treatment with London’s cellulite experts
At LipoTherapeia we have specialised 100% in skin tightening and cellulite reduction for more than two decades and 20,000+ sessions.
This is all we study and practise every day and have researched and tried hands-on all the important skin tightening equipment and their manufacturers.
As strong, deep acting radiofrequency and deep-acting, high-power ultrasound cavitation are the technologies of choice for skin tightening and cellulite reduction, we have invested in the best RF/ultrasound technologies in the world.
(Of course, we keep looking for new technologies every day and if/when a better technology materialises we will be the first to provide it. However, we will never follow the latest ineffective gimmick, just because it’s good marketing to offer the latest hyped up - yet ineffective and/or unsafe treatment.)
Furthermore, over the last two decades we have developed advanced RF and cavitation treatment protocols in order to make the most of our technologies, for maximum results, naturally and safely.
And for even better, faster results, we now combine our RF/ultrasound treatments with high-power red/infrared light LED treatment.
Our radiofrequency/ultrasound/LED treatments are comfortable, pain-free, downtime-free, injection-free, 99.5%+ safe and always non-invasive.
(No unsafe and ineffective RF microneedling or HIFU and no safe but ineffective acoustic wave therapy, superficial RF (bipolar/tripolar/multipolar etc), low power RF/cavitation, electrical muscle stimulation, lymphatic massage, cupping, dry brushing and no ridiculous bum bum creams.)
Our focus is on honest, realistic, science-based treatment, combined with caring, professional service, with a smile.
We will be pleased to see you, assess your cellulite, skin laxity or fibrosis, listen to your story, discuss your case and offer you the best possible treatment.
Check prices and book an expert cellulite / skin tightening treatment at our London clinic.
Look Inside Your Skin™ with a Cellulite Ultrasonography™ scan, exclusive to LipoTherapeia in London, and assess your cellulite, skin laxity, post-liposuction fibrosis and more
We are proud to be the first and only cellulite clinic in the world to offer Cellulite Ultrasonography™ to our clients, for accurate assessment, better treatment and enhanced results. Since 2022 we have assessed and provided valuable insights to hundreds of clients to better understand their specific case, see how their skin looks from inside and make informed decisions.
You can now book your Cellulite Ultrasonography™ session and assess your:
Cellulite
Skin laxity
Lipedema
Subcutaneous fat levels
You can also assess the presence and severity of fibrosis and adhesions after:
Liposuction in all its forms, including vaser, smart lipo, bodytite, abdominoplasty/tummy tuck, thigh lift, arm lift, lipedema surgery etc
Cellulite surgery, such as cellulaze, cellutite, cellfina, subcision etc
Face-lift surgery
Non-surgical procedures, such as RF microneedling, extreme intensity HIFU, extreme intensity RF, extreme intensity ultrasound etc
Everything will be shown and explained to you clearly and you can see and understand how the different structures inside your skin affect your appearance.
If there is scar tissue / fibrosis, those will be clearly seen and you can differentiate between fibrosis, water retention or unremoved fat after all types of cosmetic surgery or harsh non-surgical procedures such as RF microneedling, extreme intensity HIFU etc.
(DISCLAIMER: Please note that this service is for your informational purposes only and does not constitute medical diagnosis or advice.)
The 45’ appointment includes full assessment and consultation and optional treatment plan for cellulite reduction and/or skin tightening.
If you do wish to have treatment with us, the ultrasound scan, assessment and consultation will be used to optimise your course of treatments and maximise your results.
The Cellulite School™: Get advanced training in cellulite reduction and skin tightening
Why train with The Cellulite School™?
We all know that training in cellulite reduction and skin tightening is as basic as it gets. It is typically a 4-6 hour training, involving only basic instruction from the manufacturer on how operators can use the machine; lots of myths, erroneous information and misconceptions; and some basic health and safety on how to use the machine.
There is no proper, real training in the science or cellulite, skin tightening, radiofrequency, ultrasound and all related technologies is non-existent - worldwide.
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Service available via Zoom or at our central London practice.
Learn more or check prices and book training at our London clinic or via Zoom.