“I have been formulating skincare products (especially anti-cellulite products) for more than 20 years and if there is one herbal extract I would use that would be centella asiatica. All its four triterpenes have multiple action against cellulite and that applies to asiaticoside too, the subject of this article.”
The centella asiatica molecule asiaticoside eliminates free radical damage and senescence in blood vessels
Asiaticoside from Gotu Kola prevents oxidative damage and reverses all markers of oxidation in endothelial cells
In addition, asiaticoside partially reverses cell senescence
Asiaticoside in cellulite creams and nutritional supplements
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
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Asiaticoside from Gotu Kola prevents oxidative damage and reverses all markers of oxidation in endothelial cells
Asiaticoside and the other three centella asiatica main active molecules (asiatic acid, madecassic acid, asiaticoside and madecassoside) are known for their multiple action against whole body ageing, skin ageing and cellulite.
In this new study of human umbilical vein endothelial cells (HUVECs), asiaticoside was found to reverse all markers of oxidative stress, a major cause of body ageing.
Furthermore, asiaticoside restored antioxidant markers, such as SOD (superoxide dismutase), NO (nitric oxide) and GSH-Px (glutathione peroxidase), after oxidative insult.
In addition, asiaticoside partially reverses cell senescence
Plus asiaticoside significantly reversed senescence-associated beta-galactosidase (SA-β-gal) activity, a marker of cell senescence. Senescence is now widely accepted as a major cause of ageing and whole body inflammation - and consequently cellulite.
Given its anti-senescence properties, asiaticoside can be used as part of anti-senescence / senolytic regime for blood vessels and entire body.
Asiaticoside in cellulite creams and nutritional supplements
Cellular senescence is an important aspect of cellulite, especially senescence of blood vessels, skin and adipose tissue. Asiaticoside - and most probably the other three gotu kola triterpenes too - help reverse senescence.
Furthermore, gotu kola helps fight cellulite via multiple other pathways, including fibrosis, inflammation, glycation and oxidative stress reduction.
So the anti-senescence action of asiaticoside, adds yet another way in which gotu kola / centella asiatica helps prevent / reduce cellulite.
Asiaticoside can be found in:
Proper, therapeutic concentrations in a very small number of quality anti-cellulite and anti-aging creams (most are very diluted and/or contain low purity active ingredients)
A small number of quality centella asiatica / gotu kola nutritional supplements (difficult to source and most are not concentrated enough but if you are lucky to find one with specific content of asiaticoside or other centella asiatica triterpenes buy it)
Centella asiatica herbal tea (easy to source on the internet these days)
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
Abstract: Background: Asiaticoside (AC) is a triterpenoid saponin found in Centella asiatica (L.) Urban extract that has a wide range of pharmacological properties. Our previous study demonstrated that AC could promote angiogenesis in diabetic wounds, but the specific mechanisms remain unknown. Objective: This study aimed to examine the effectiveness and mechanism of AC on human umbilical vein endothelial cells (HUVECs) exposed to tert-butyl hydroperoxide (t-BHP) toxicity. Methods: Senescence was confirmed using senescence-associated beta-galactosidase (SA-β-gal) activity and expression of the cell cycle phase markers p16 and p21. The levels of SOD, NO, MDA, GSH-Px, ROS were tested. Furthermore, several cell death-related genes and proteins (p53, Bax, Bcl-2 and Caspase-3) were assessed with RT-qPCR and Western blotting. Results: AC significantly reduced SA-β-gal activity, with both the suppression of cell-cycle inhibitors p16 and p21. We also found that the induced oxidative stress and apoptosis caused by t-BHP treatment resulted in the decrease of antioxidant en-zymes activities, the surge of ROS and MDA, the up-regulation of p53, Bax and caspase-3, and the decrease of SOD, NO, GSH-Px and Bcl-2. These biochemical changes were all reversed by treatment with varied doses of AC. Conclusion: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.
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At LipoTherapeia we have specialised 100% in skin tightening and cellulite reduction for more than two decades and 20,000+ sessions.
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We are proud to be the first and only cellulite clinic in the world to offer Cellulite Ultrasonography™ to our clients, for accurate assessment, better treatment and enhanced results. Since 2022 we have assessed and provided valuable insights to hundreds of clients to better understand their specific case, see how their skin looks from inside and make informed decisions.
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You can also assess the presence and severity of fibrosis and adhesions after:
Liposuction in all its forms, including vaser, smart lipo, bodytite, abdominoplasty/tummy tuck, thigh lift, arm lift, lipedema surgery etc
Cellulite surgery, such as cellulaze, cellutite, cellfina, subcision etc
Face-lift surgery
Non-surgical procedures, such as RF microneedling, extreme intensity HIFU, extreme intensity RF, extreme intensity ultrasound etc
Everything will be shown and explained to you clearly and you can see and understand how the different structures inside your skin affect your appearance.
If there is scar tissue / fibrosis, those will be clearly seen and you can differentiate between fibrosis, water retention or unremoved fat after all types of cosmetic surgery or harsh non-surgical procedures such as RF microneedling, extreme intensity HIFU etc.
(DISCLAIMER: Please note that this service is for your informational purposes only and does not constitute medical diagnosis or advice.)
The 45’ appointment includes full assessment and consultation and optional treatment plan for cellulite reduction and/or skin tightening.
If you do wish to have treatment with us, the ultrasound scan, assessment and consultation will be used to optimise your course of treatments and maximise your results.
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