hyaluronic acid and your skin

Skin hydration, anti-ageing, wound healing, water retention, cellulite

Hyaluronic acid (also known as hyaluronate or hyaluronan) is the most important moisturising molecule in the human body, an essential component of skin and connective tissue, and an invaluable anti-ageing and connective tissue restructuring active ingredient. Hyaluronic acid comes in various sizes (molecular weights), with the higher sizes forming a film on the skin and the smaller ones penetrating in the deeper dermal layers.

Low molecular weight (LMW) hyaluronic acid comprises small size hyaluronic acid molecules and can penetrate deeper than normal hyaluronate. In addition, LMW hyaluronan itself is also a penetration absorber for other active ingredients in body / face creams. 



For all these reasons, LMW hyaluronic acid is of great importance as an active ingredient in anti-cellulite, leg wellness, anti-ageing and under-eye creams. Hyaluronic acid creams are now popular for dry, aged skin and to fill wrinkles and fine lines [the Celluence® cellulite and leg wellness creams are the only creams in the world with 99% pure LMW hyaluronic acid - less than 10 kDa - plus 39x other natural anti-cellulite actives].




4 of the many ways hyaluronic acid

can help boost skin healing and fight skin aging, water retention and cellulite



4/ Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period.

Abstract: BACKGROUND: Hyaluronan (HA) has critical moisturizing property and high water retention capacity especially for human skin. This study aimed to evaluate the effect of oral intake of HA. METHODS: The mean molecular weight (MW) of HA is 2 k and 300 k. Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks. The skin wrinkles were evaluated by image analysis of skin wrinkle replicas, and their skin condition was evaluated using a questionnaire survey. RESULTS: During the study period, the HA groups showed better level of the whole sulcus volume ratio, wrinkle area ratio, and wrinkle volume ratio than the placebo group. After 8 weeks of ingestion, the HA 300 k group showed significantly diminished wrinkles compared with the placebo group. Skin luster and suppleness significantly improved after 12 weeks in all groups compared with the baseline. CONCLUSION:
The results suggest that oral HA (both HA 2 k and HA 300 k) inhibits skin wrinkles and improves skin condition.



3/ Novel curcumin - hyaluronic acid conjugate improves curcumin's wound healing and antioxidant activity

Curcumin is a promising wound healing agent but its clinical application is limited due to being undiluted to water and lack of stability. However, curcumin conjugated to hyaluronic acid, has been found to be better than curcumin for fighting free radical damage and wound healing than plain curcumin.

[Source: Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation]



2/ Phlebitis ulcers heal with the aid of herbal cream consisting of horse chestnut, butcher's broom, allantoin and hyaluronic acid

This herbal compound, in combination with compression garments, significantly improved inflammation, healing time and pain in phlebitis, in relation to compression garments alone. Ivy extract in the cream contributed to pain reduction; horse chestnut, butcher's broom and grape seed extract reduced inflammation; and allantoin, gotu kola and hyaluronic acid aided sore healing. In patients who applied both the cream and the compression garment pain stopped in 72 hours, inflammation disappeared in one week, tissue swelling stopped in one week and healing was complete in 4 weeks.

[Source: Multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs]



1/ 50kDa hyaluronic acid reduces fat and fights obesity...

...by decreasing adipose tissue hypertrophy, inhibiting adipogenic differentiation, enhancing PPAR-α and suppressing PPAR-γ expression

[Source: Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice]