The anti-ageing action of the pine extract dehydroabietic acid

  • Dehydroabietic acid (DAA) is a naturally occurring tree resin chemical, found in pine and for trees and it has antimicrobial, antiulcer, and cardiovascular activities.
  • A new study has now shown that dehydroabietic acid also has anti ageing and life extension properties, by activating SIRT-1, the most well known life extending / anti ageing protein. 
  • SIRT-1 is the protein also activated by the most well-known anti-ageing / life extending botanical extract know today, resveratrol, so both phytochemicals act in the same - or at least similar - way. Resveratrol is famous for being the most important anti-ageing active in red wine and is considered the reason behind the so called "French Paradox". 
  • The authors of the study state that "the direct activation of SIRT1 enzymatic activity suggests the potential use of this natural diterpene (dehydroabietic acid), or related compounds, in age-related diseases or as a preventive reagent against the aging process".
  • Practically, dehydroabietic acid could be used as an active ingredient in anti ageing creams and - pending further research and safety evaluation - as an anti ageing supplement. 
  • Source: The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1,
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Rhodiola rosea extract can be used in the fight against obesity and cellulite

  • The Rhodiola rosea herb is well known for it's anti-fatigue, anti-stress and anti-inflammatory activity and for this reason is very popular as a food supplement. 
  • Rhodiola is also known to improve glucose and fat metabolism and a new study has now shown that it may also be used in the fight against obesity, as it also possesses anti-adipogenic and lipolytic activity.
  • Specifically, the study has shown that the combination of the Rhodiola rosea extract chemicals salidroside and rosavines had the following effects on visceral fat cells: they induced adipocyte apoptosis (i.e. early fat cell death), lipolysis (i.e. fat release from fat cells), reduced triglyceride incorporation (i.e. reduced absorption of fat into fat cells) and reduced the levels of PPAR-gamma, a protein that stimulates adipogenesis (new fat cell creation).
  • In summary, salidroside and rosavines from Rhodiola hold great promise in the fight against overweight and it's complications (in the form of a food supplement) and in their fight against cellulite (in the form of an anti-cellulite cream rich in those two phytochemicals).
  • Source: Effects of Two Different Rhodiola rosea Extracts on Primary Human Visceral Adipocytes,
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Fat tissue inflammation caused by injection-based mesotherapy

  • Mesotherapy Is a procedure that involves multiple injections of homeopathic remedies, vitamins or different chemicals into the skin for aesthetic or medical purposes. 
  • Mesotherapy is commonly used in aesthetics as an anti-ageing, body / face contouring and anti-cellulite treatment. Its effectiveness varies, depending on the chemicals injected and on practitioner skill and it is usually accompanied by bruising, pain and occasionally infection, inflammation or systemic side effects, such as fainting.
  • In fact, the cases of inflammation and/or infection reported have risen the last few years with the increase in the number of procedures that are performed and the use of more and more harsh agents, such as concentrated deoxycholic acid for fat reduction. Mesotherapy-induced panniculitis, in particular, i.e. Inflammation of the fat tissue, is becoming more common, according to a recent study. Such cases are typically treated with antibiotics or anti-inflammatory drugs.
  • It is important to note here that electro-mesotherapy, also known as needle-free mesotherapy, which allows the absorption of natural actives Into the skin without the need of injections, has all the benefits of injection-based mesotherapy, without any of the side effects and complications - but only if high quality, concentrated electro-mesotherapy cream-gels are used (electro-mesotherapy with poor quality / low concentration cream-gels is not very effective). 
  • Source: A case of mesotherapy-induced panniculitis,
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Cocoa reduces inflammation in fat tissue - implications in cellulite reduction

  • Fat tissue is quite often in a chronic state of low-grade inflammation, which is a risk factor for diabetes and cardiovascular disease. Furthermore, adipose tissue inflammation is one of the aspects of cellulite, which is related to glycation and oxidative damage, also found in cellulite.
  • Cocoa (Theobroma cacao) is a polyphenol-rich food with well-known anti-inflammatory activities which can help fight fat tissue inflammation - and consequently cellulite.
  • A new study has now found how cocoa fights adipose tissue inflammation caused by high fat diet: cocoa supplementation reduces the levels of several inflammation-related markers in fat tissue, including TNF-alpha, iNOS, arachidonic acid, adipose-specific phospholipase A2 and cyclooxygenase-2 (COX-2) and plasma endotoxin by up to 60%.
  • This practically means that cocoa, especially high-polyphenol cocoa, can be safely and effectively used to fight inflammation in fat tissue and help reduce cellulite. 
  • Furthermore, high polyphenol cocoa extract may be used in anti-cellulite creams to help fight inflammation in cellulite. This is in addition to cocoa's well-known skin firming and circulation enhancing properties, which also help fight cellulite, offering a triple effect against cellulite. 
  • Dark chocolate, a food rich in cocoa polyphenols but also in sugar, is not an amazing anti-inflammatory food (sugar is known to promote inflammation), but it is still better than any other sugar-rich food. So practically, chocolate can not be used to fight fat tissue inflammation or cellulite, despite it's high cocoa content.
  • Source: Dietary cocoa reduces metabolic endotoxemia and adipose tissue inflammation in high-fat fed mice,
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Botox for fat loss? Are you serious?

  • I saw a client a couple of days ago who came for face contouring on the under chin / jowl area and to my surprise she said that she also received Botox injections on that area for fat loss. 
  • As is well known, botulinum toxin (Botox) is a nerve toxin which relaxes muscles in order to reduce the appearance of wrinkles (muscles are attached to the skin of the face and when they contract they cause wrinkles - by relaxing the muscles you gradually soften the wrinkles).
  • However, Botox has no effect whatsoever on fat cells, so the injections on the under chin / jaw area  were suggested out of pure greed and they will have no other effect other than reduce the bank balance of my client and increase that of the Botox provider.
  • I hear about similar misleading claims every day: liposuction that reduces cellulite (this is impossible), cellulite reduction with one session (ditto), fillers injected in all the wrong places and Botox injected to tone up facial muscles (which is the opposite of what Botox does) - the list is endless.
  • it is sad to see people being misled by unscrupulous practitioners, which has the end result of making people cynical and resentful and hurts the entire aesthetic and cosmetic industry... 
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How to help prevent sun damage by blocking COX-2

  • COX-2 is one of the most common inflammatory enzymes in the body and a recent study has discovered that levels of this enzyme are elevated in collagen cells (fibroblasts) and keratin cells (keratinocytes) of women who had sun damaged skin - these levels were found to be much higher than in women with normal ageing.
  • The authors of the study explain that  "The results indicate that COX-2 (cyclooxygenase-2) may be involved in the pathogenesis of the photoaging process. Inhibition of expression or activity of the enzyme may find application in photoaging treatment and/or prophylaxis."
  • Practically this means that eating foods rich in natural COX-2 blockers, such as oily fish and turmeric, taking fish oil or turmeric food supplements or applying anti-ageing creams rich in boswellia extract or curcumin extract, all of which are known to block COX-2, can help partially prevent sun damage. 
  • Source: Increase in cyclooxygenase-2 (COX-2) expression in keratinocytes and dermal fibroblasts in photoaged skin,
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How the fat cell hormone leptin affects breast cancer

  • "More than one million new cases of breast cancer are diagnosed worldwide each year and more than 400,000 deaths are caused by the disease. The origin of this pathology is multifactorial and involved genetic, hormonal, environmental and nutritional factors including obesity in women after menopause. The role played by the adipose tissue and their secretions, ie adipokines, is beginning to be recognised."
  • Fat cells secrete hormones, called adipokines, which can affect breast cells both locally in the breast (breast cells, including breast cancer cells are surrounded by fat cells, especially in obese women) and remotely, via the blood circulation.
  • Leptin, a fat cell hormone whose levels are elevated in obesity or overweight, appears to be strongly involved in breast cancer cell creation (mammary carcinogenesis) and may contribute to inflammation, oxidative damage and cancer cell immunity, especially in obese patients (such patients have increased potential for metastasis and greater risk of death from cancer.
  • Leptin levels are naturally reduced by eating a diet low in sugar, carbs and saturated fat and rich in fruit, vegetables and oily fish, increasing exercise and in general by losing weight and all those measures are also known to contribute in the fight against beast cancer. Several herbal extracts, such as curcumin, EGCG from green tea and dozens others are also known to reduce fat cell inflammation, oxidative stress and also help prevent cancer.
  • Source: Leptin, adipocytes and breast cancer: Focus on inflammation and anti-tumor immunity,
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How do cellulite creams compare to cellulite treatments?

  • First of all it is important to note that, due to the multi-faceted nature of cellulite, most cellulite creams do not work, usually due to low concentration of actives in most creams. Likewise most cellulite treatments are not very effective due to low equipment specification / therapist knowledge of cellulite. However, a small number of treatments and creams are effective and the differences are as follows.
  • A good cellulite treatment will provide more impressive results and much faster than a good cellulite cream, but it also tends to be much more expensive. A typical quality cellulite treatment costs £150-£250 per session (price is not the best indicator, but these are the average prices for the few good treatments that exist) and a course of 6x sessions is typically recommended, bringing the total to £900-£1500 for satisfactory results. With treatments once to twice a week, good, long-term results will be seen in about 4-5 weeks.
  • A good cellulite cream takes more time to produce results but it much more economical. A typical quality cellulite cream costs £100-£150 per one month supply and for good results 3-month use is recommended, bringing the total to £300-£450. 
  • Of course, some immediate, short-term results may be seen in as little as a few hours, with either treatments or creams, and the first long-term results may appear in as little as 2 weeks in both cases, but for long-lasting, good results these numbers of sessions or creams are typically recommended.
  • Mild cases may need less treatments (even as little as 3x) and severe cases may need more treatments (even as many as 24x). The same applies to creams: mild cases may require just one month's use of cream, while the very severe cases may need up to 6 months' use. It is important to note here that, contrary to misinformation in the press and on the web, cellulite cannot be completely eliminated with ANY method, so here we are talking about improvement according to severity of cellulite - not complete removal.
  • So in summary it can be said that a quality cellulite cream offers more value for money but acts more slowly, while a quality cellulite treatment is more expensive but acts much faster.
  • Naturally, the combination of both, i.e. a quality treatment and a quality cream, will offer the fastest and more impressive results and will provide a good balance between value for money, speed of results and effectiveness.
  • In all cases, healthy diet and regular exercise are essential for maximum results and also to get the best value for money out of treatments and creams. There is no point spending £300 or £3000 for treatments and creams and undermine the whole process with poor diet, alcohol and inactivity. 
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FGF-21 stimulates thermogenesis in fat cells

  • Fat cells are generally known as fat storage depots but the last few years there is tremendous interest in fat burning in fat cells themselves, as opposed to the traditionally known fat burning in muscles and liver.
  • Fat burning fat cells are called brown fat cells, taking their name from their darker colour (as opposed to white fat cells which only store fat), and research has focused on how to boost their population in order to control obesity.
  • However, it was recently discovered that a protein called FGF-21 (Fibroblast Growth Factor 21) can stimulate fat burning in white fat cells, without the need of brown fat cells or the "browning" of white fat cells, which only occurs after exposure to cold, intense exercise or with certain drugs / herbal extracts.
  • It is still early days, but this discovery can lead to the development of drugs and the discovery of natural agents that can help burn fat in actual white fat cells, which comprise 99% of fat cell population in humans.
  • This can lead to effective fat and cellulite reduction and it is a really exciting development.
  • Source: Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue,
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How cigarette smoke causes insulin resistance and thereby contributes to PCOS

  • "Come to Where Insulin Resistance Is, Come to AMPK Country", says a recent research paper, paraphrasing the famous cigarette brand advertising slogan (
  • It is well known that cigarette smoking contributes to insulin resistance, i.e. the inability of body cells to properly recognise insulin. Insulin resistance in partially responsible for diabetes, heart disease and a host of other diseases, including polycystic ovary syndrome (PCOS).
  • Insulin resistance is usually found on overweight people, so the fact that smoking causes both weight reduction and insulin resistance perplexed scientists. Now scientists have discovered how smoking does that.
  • Nicotine, found in cigarette smoke,  activates a protein called AMP-activated protein kinase α2 (AMPKα2) which ultimately ends up blocking the anti-lipolytic effect of insulin. This has the positive effect of increased lipolysis - and consequently fat reduction - but also increased release of free fatty acids from fat cells into the circulation. Free fatty acids are known to cause insulin resistance. This explains how smoking keeps people slim yet makes them more prone to insulin resistance and associated conditions, such as PCOS, which can cause acne, scalp hair loss and body & face hair growth in women. 
  • The most common treatment for PCOS is the contraceptive pill, which blocks the testosterone production caused by PCOS. However, the pill also causes cellulite, weight gain, mood issues and low sex drive - and in combination with smoking it can cause blood clots and breast cancer. 
  • Furthermore, smoking causes cellulite due to poor circulation, glycation and collagen degradation. 
  • Moral of the story: ladies, if you suffer from PCOS, quit smoking now! Smoking may keep you slim but it also gives you body and face hair growth, scalp hair loss, acne and of course it is not the best thing for your ovaries either. Alternatively, if you want to continue smoking and avoid PCOS by taking the pill, you may end up with cellulite, weight gain and blood clots - not to mention the increased risk of breast cancer. Is it worth it?
  • Source: Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo,
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Cranberries reduce fat accumulation - and consequently cellulite - by blocking fat metabolism

  • Cranberries have previously been found to decrease fat accumulation in fat cells by inhibiting their growth (adipocyte differentiation) and by blocking specific fat cell proteins, such as C/EBPalpha and PPAR-gamma. 
  • However, new research has now shown that cranberries inhibit several other fat metabolism proteins (LPL, HSL, FAS, leptin and perilipin), which resulted in reduced fat accumulation and, as the authors of the study put it, reduced "adipose tissue mass production".
  • In summary, cranberries are not only helpful in the fight against obesity and cellulite because of their low calorie content and also due to their direct effect against fat cells and their metabolism.
  • This effect is probably due to cranberries' high content of proanthocyanidins and other polyphenols, as these phytochemicals are renowned for their anti obesity effect.
  • In summary, cranberries, unsweetened cranberry juice, cranberry extract food supplements and cellulite creams rich in cranberry extract or proanthocyanidins can be helpful in the fight against cellulite and / or overweight and obesity. 
  • Source: Cranberries (Oxycoccus quadripetalus) inhibit lipid metabolism and modulate leptin and adiponectin secretion in 3T3-L1 adipocytes,
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How can I know what is the best radiofrequency machine for skin tightening and cellulite removal?

  • Radiofrequency is widely accepted as being the most effective cellulite reduction and skin tightening technology available today for both face and body. By applying intensive heat on collagen and fat cells, radiofrequency helps increase skin tightness and reduce fat, thereby improving the contour and texture of body and face.
  • However, not all radiofrequency treatments are the same: effectiveness can range from almost zero to amazing. There are hundreds of radiofrequency machines on the market, for both home and professional use. With such variability in technology (in addition to the variability in therapist training and treatment creams / gels - which also play a very important role), the following question arises: how can a customer know which treatment is the best? This is a very common question I hear from prospective clients, as they are confused by conflicting information from both the press and clinics / salons. Predictably, everyone claims their treatment or machine is the best. 
  • Unfortunately, as a simple customer you can't know what is the best machine - not at least without technical knowledge. Most therapists, even doctors, don't know how to choose a good machine - they just go according to the sales pitch or fame. But fame is not an accurate way to judge a piece if equipment. One of the most famous anti-cellulite machines on the market simply "doesn't work", yet it still keeps selling like hot cakes - both in terms of machine sales and treatment sales. I go to professional exhibitions and I see that most sales people cannot even give me any technical specs for their equipment. Most salon and clinic buyers cannot even understand the specifications. They depend on fake before and after photos, popularity/fame, "what the competition does" and dodgy "evidence". Now, if the therapists do not know how to choose, how can you?
  • The obvious question is, how do I think I know what's best? Well, I didn't always know, but at least before I bought a machine I researched the industry for three years. Having a university training in Physics helped a lot, as it allowed me to know what the specifications of different machines mean.
  • It was a successful choice and after I bought the machine I studied the further Physics of radiofrequency and their practical application in detail for several months. This allowed me to develop my own treatment protocols with different settings and treatment creams / gels (believe me, treatment creams / gels play a huge role) in order to maximise the results for my clients and make the treatment comfortable and pleasant - in contrast to most RF treatments which need to be painful to be effective.
  • Within a year I upgraded to a better machine with the exact settings I need for my protocols and creams and this is the equipment I use for the last 3 years. 
  • I may be totally wrong - and we clearly do not promise any miracles - but based on physics, specifications and all this experience, I believe that at LipoTherapeia we currently offer the strongest yet most comfortable radiofrequency treatment for cellulite reduction and skin tightening for the face and body.
  • You may take my word for it or research further by looking at how different specifications affect the effectiveness of radiofrequency treatment, so that you make your own informed decision and choose the ideal treatment for you. In summary, if therapists don't know, then you can't know, unless you look at specifications and ask the relevant questions (please look at the "radiofrequency" tag, below).
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Slimming and dying with dinitrophenol

With dinitrophenol you lose weight quickly but you also literally fry yourself from within

  • A few days ago a British woman diet after taking the "slimming supplement" DNP (Di-Nitro-Phenol). Dinitrophenol is illegal in the UK as a slimming pill but unfortunately it is still allowed to be sold for other uses.
  • Dinitrophenol diverts the energy production mechanism of each cell in the body from useful energy production for the needs of cells and organs into heat energy production. As a result, the person who takes dinitrophenol loses weight, but with dire consequences in their health.
  • Because the dose of efficacy of dinitrophenol is quite near the dose of severe organ damage or death, dinitrophenol is an extremely dangerous way to lose weight.
  • When you take dinitrophenol you experience massive heat (high temperature) in your body, as a result of intense heat production in cells (thermogenesis).
  • However, as almost all the energy produced in the cell's mitochondria ends us as heat, no energy is left in the cell for vital function and as a result the cell is literally starved and suffocated of energy. Furthermore, the massive and uncontrolled fatty acid oxidation leads to free radical production, which can also damage cells and organs. This combined effect, i.e. energy starvation and oxidation/free radical damage, can lead to organ failure or - with higher doses - death, as happened to the British dieter - and several other in the past - a few days ago. 
  • The thermogenesis produced by DNP is indiscriminate and uncontrolled, unlike the thermogenesis / heat production occurring specifically in fat cells after eating foods such as wakame or oily fish, which is quite mild and targeted, i.e. limited to fat cells only.
  • With the consumption of such foods (or supplements) a protein called UCP1 stimulates fat cells to burn fat for heat production. Unlike with DNP, this is not a life-changing effect, i.e. there is no massive heat production or slimming - but then again it does not cause damage to health either. In fact, due to the other beneficial effects of omega-3 in oily fish or the antioxidants in wakame, consuming such foods improves health and helps with slimming, than damaging it for the sake of slimming.
  • Closing this post, I would like to reiterate that dinitrophenol is an extremely dangerous substance and you should not even consider using it for weight loss, preferring the slower and healthier weight loss thermogenic effect of natural foods instead.
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Which is your favourite summer weight loss / anti-cellulite food?

  • If I had to choose a weight loss food, that would be lightly grilled wild salmon with wakame  seaweed and pomegranate seed salad with green tea. It makes a light and refreshing meal, full of healthy weight loss ingredients.
  • Oily fish is proven in human trials to help with weight loss and is one of the very few foods that do so - as opposed to foods like vegetables which just prevent weight gain by not containing too many calories
  • Farmed salmon contains too little long-chain omega-3 oil to have a good effect, so only wild salmon can deliver the goods
  • Wakame seaweed contains fucoxanthin, which is also proven in human trials to help with weight loss, especially if combined with pomegranate seed oil
  • Human trials have also shown that long-chain omega-3 fatty acids enhance the effect of fucoxanthin
  • Wakame can make a nice salad with some lemon drizzled over it and a few sesame seeds and pomegranate grains poured over
  • A cup of green tea is ideal with this food, as it contains the phytochemical EGCG that enhances the effect of fucoxanthin
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Acoustic wave therapy does NOT reduce fat and cellulite

  • A recently published study on the effectiveness of acoustic wave therapy (AWT) concluded that the application of either the radial and planar form of this technology reduced fat but the change was not statistically significant, i.e. it was so small it could be a statistical error. Non-statistical changes usually refer to a change of 1-2%, which basically mean that the treatment practically does not work.
  • This finding correlates well to the results of our extensive assessment of acoustic wave therapy almost 10 years ago. That was long before this technology became famous after a misleading PR marketing campaign by "a leading medi-spa" here in London, that specialises in selling miracles to it's customers.
  • After a month of applying the treatment on several of our customers (for several sessions each), the results were "nil". After the trial, being honest to our clientele we returned the machines and continued providing our normal treatments (we tried two different AWT machines, one planar and one radial, both the best in the industry).
  • Unfortunately, uninformed people still try to use a technology designed to treat hard tissues (bones, tendons and ligaments), in order to treat the softest tissues of all, fat and cellulite. It beggars belief...
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How fat cells damage muscles and lead to wasting and weakness

  • In a previous research paper presentation on this website, we reported that fat cells accumulating in muscle tissue undermine the muscle tissue, leading to weakness and wasting.
  • Now a new paper published in the journal diabetes shows how visceral fat (deep stomach fat, also known as "beer belly" or just "belly fat") also undermines muscle tissue throughout the body.
  • Specifically it was found that in obesity, visceral adipocytes (fat cells) secrete inflammatory proteins (IL-6 and IL-1β) that reduce the contractile proteins in muscles, leading to muscle weakness and muscle wasting. Superficial fat tissue (basically, fat under the skin) was much less potent in that respect.
  • In summary, this paper shows that belly fat is not only a risk factor for diabetes and cardiovascular disease but also for muscle weakness and muscle loss.
  • Stress, alcohol, a high carb diet and inactivity are the main reasons for the accumulation of visceral / stomach fat
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How hydrolysed collagen and astaxanthin improve skin elasticity

  • It is well known that hydrolysed collagen enhances skin firmness, as it provides peptides which are ready for use by skin cells in the production of collagen.
  • Furthermore, it is also well-known that most "antioxidants" (polyphenols and carotenoids) assist in the prevention of collagen and elastin damage and boost it's production.
  • Therefore, it is no surprise that a new food supplement that contains hydrolysed collagen and astaxanthin (a carotenoid contains in prawns and salmon) can help with skin firmness and anti-ageing.
  • Specifically, researchers in Korea have found that the combination of the two nutrients improve skin hydration and skin elasticity on sun-damaged skin, after 12 weeks of use.
  • At tissue level, the researchers have found that the precursor or collagen "pro-collagen type 1" increase and enzymes that break down collagen (the metalloproteinases MMP-1 and MMP-12) decrease with supplementation.
  • Unfortunately, the supplement did not make any difference with regard to UV-induced DNA damage.
  • As a take home message, derived from this and other studies, the supplementation of collagen, hyaluronic acid and antioxidants from vegetables, herbs and fruits (anything from tomatoes to blueberries) is ideal to prevent ageing and maintain skin firmness and elasticity.
  • Creams rich in the same nutrients can also provide the same protection externally, in addition to internal protection from food and supplementation.
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Whey protein is not that innocent - what to look for when you buy a whey protein powder

  • Whey protein is a great way to boost your protein intake and thereby ensure muscle tissue repair and growth and skin repair and firming (muscle and skin is made of protein).
  • However, whey protein is also an immune-stimulating protein as it contains many immune compounds. Most whey proteins that you can buy in "health food" and bodybuilding stores (probably 95% of the market) contain denatured (damaged) immune compounds due to it's harsh processing, such as cross-flow filtration, microfiltration, isolate filtration, hydrolysation and ion exchange.
  • Denatured immune compounds may irritate the immune system causing intolerance reactions on sensitive people, which although mild in most cases, in the long run are detrimental for the immune system.
  • For this reason it is essential to ensure that you buy pure, "native", non-denatured whey which is as close as to the original component of milk, as possible. Of course, whey produced from organic or grass fed cows is preferred to that produced with industrial farming methods that include hormones, pesticides and other pollutants.
  • A real, pure whey protein provides immunoglobulins / IgG (including among others bovine serum albumin, alpha-lactalbumin and beta-lactoglobulins), lactoferrin (which ensures proper iron supply into the cells that needs it) and cysteine which is a precursor of glutathione, the most important antioxidant and detoxification factor in the human body.
  • Because of it's powerful immune-stimulating effect, whey should not be used excessively or continuously without breaks. But even more importantly, denatured whey should not be used at all, as it can gradually lead to unwanted immune stimulation (intolerances, allergies, auto-immunity etc).
  • So in summary, pure, native, non-denatured protein is great as a protein supplement if it is not used excessively or without breaks, while denatured whey should not be consumed at all due to the damage of immunoglobulins contained in it during the manufacturing process.
  • Please note that whey protein also stimulates excessive insulin secretion, which can either be beneficial for muscle building or detrimental to health, according to the time it is consumed. We have analysed this aspect of whey on another article on this website.
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Whey protein, insulin, skin firmness and cellulite

  • Whey protein is the best whey protein you can use after weight or even cardiovascular training. It is the highest biological quality protein you can have, as it contains all the essential aminoacids in a very absorbable form. In addition, because whey significantly boosts insulin, it further boosts it's own absorption by muscle cells (insulin boosts the absorption of protein by muscle cells).
  • Most women today do not have enough protein and this is the reason so many women suffer from loose skin these days: skin is made of protein and with a low protein diet the body uses up the protein stores in the skin and never replaces them.
  • So, of most women, the addition of whey protein in the diet is recommended after training, at a daily dosage of about 20-30 grams. This will ensure that both muscles and skin are replenished with all the necessary aminoacids they need for tissue repair, muscle growth and skin firming.
  • However, although whey's insulin production stimulation is a blessing after training, it may prove a curse if you are sedentary. This is because when you are sedentary and eat carbs or fat, excessive insulin stimulates the absorption of carbs and fat by fat cells, leading to obesity and cellulite. On the other hand, if you are sedentary and on a low carb/low fat diet, excessive insulin will lead to hypoglycaemia, low energy and dizziness. In general, excessive insulin production at any other time except after exercise is not a good thing for health, as it leads to obesity and is a risk factor for diabetes and cancer.
  • You may reduce the insulin-stimulating effect of whey by mixing it with fibre (such as chia seeds, flax seeds) and healthy fat (such as coconut fat), which will slow down it's digestion and the consequent insulin release, but the total amount of excess insulin secreted will still remain the same, so this is not a perfect solution.
  • So, in summary, a high quality whey protein is ideal as a muscle-buidling, skin firming supplement, immediately after real vigorous exercise (gentle Pilates and Yoga do not qualify), with some carbs (immediately after exercise is the best time to have carbs). And it is detrimental to health, your fat stores and cellulite if it is taken when sedentary.
  • Whey is also a strong immune-stimulating food, which may be either beneficial or detrimental to health, depending on the quality of the product and how it is used. We have analysed this aspect of whey on another post on this website.
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How to reduce cellulite by fighting glycation, hypoxia and inflammation

  • At a recent research paper presentation, we looked into how glycation and hypoxia (low tissue oxygenation, caused by poor circulation) cause fat tissue inflammation throughout the body and cellulite, in particular. at skin level. On this article we provide a simple holistic strategy against hypoxia, inflammation and glycation to help improve the health of your fat tissue and reduce cellulite.
  • Hypoxia can be reduced by regular exercise and a healthy diet rich in oily fish, vegetables and fruits and poor in sugar and saturated fat. A highly concentrated anti-cellulite cream that enhances circulation and reduces fat can also be of help, as can a strong anti-cellulite treatment, such as high power radiofrequency or strong anti-cellulite massage.
  • Glycation can be reduced by seriously restricting sugar, refined carbohydrates or excessive intake of carbs (even the complex ones). Supplementing with the anti-glycation aminoacid carnosine is essential. Again, a highly concentrated anti-cellulite cream that contains in meaningful quantities the aminoacids carnosine and other anti-glycation plant extracts (such as centella, pine bark extract, green tea extract, dihydromyricetin and other) can also be of help.
  • Low grade inflammation can be reduced by a diet poor in sugar, trans fats and omega-6 fatty acids and rich in oily fish, vegetables, fruits and herbs such as turmeric. A highly concentrated anti-cellulite cream, rich in anti-inflammatory ingredients such as curcumin and 18-beta glycyrrhetinic acid may also be of help.
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