Curcumin and your skin

Inflammation, aging, oxidative damage, cellulite

Curcumin, found in turmeric (curcuma longa), is one of the most widely researched natural actives known today, with potent anti-ageing, antioxidant, skin lightening, anti-inflammatory and lipolytic activity.

 

Curcumin cream

For all these reasons, curcumin is of great importance as an active ingredient in anti-ageing, anti-cellulite, leg wellness, contouring, skin whitening and under-eye creams [the Celluence® creams are the only cellulite creams in the world with high concentrations of 95%+ pure, high availability curcumin, plus 39x other natural anti-cellulite actives].

 

 

7+ ways Curcumin

can fight oxidative damage, inflammation, ageing and cellulite

 

 

7/ Novel curcumin - hyaluronic acid conjugate molecule improves curcumin's wound healing and antioxidant activity

Curcumin is a promising wound healing agent but its clinical application is limited due to being undiluted to water and lack of stability. However, curcumin conjugated to hyaluronic acid, has been found to be better than curcumin for fighting free radical damage and wound healing than plain curcumin.

[Source: Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation]

 

 

6/ Curcumin is a stronger and broader anti-inflammatory than the steroid drug prednisolone...

...allowing it to combat numerous inflammatory diseases via multiple pathways (TNF-α and IL-6 expression by macrophages, IL-8 expression by colon epithelial cells, ROS production in polymorphonuclear leukocytes and platelet activation in whole blood). Specifically, curcumin is as good inhibitor as prednisolone for TNF-alpha and IL-6 and better than prednisolone for ROS, IL-8 and fibrinogen binding.

 
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[Source: Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro]

 

 

5/ Curcumin significantly improves endothelial function...

...arterial compliance and arterial stiffness through its effects on inflammation, oxidative stress, nitric oxide bioavailability, and structural proteins of the artery

[Source: The Emerging Role of Curcumin for Improving Vascular Dysfunction: A Review]

 

 

4/ Curcumin helps burn fat by stimulating beige fat thermogenesis...

...by stimulating beta-3 adrenoreceptor gene expression and elevating the levels of plasma norepinephrine, albeit at quite high concentrations (50-100mg/kg of body weight). However, curcumin has been found in other studies to have a direct lipolytic and anti-adipogenic action, via additional mechanisms to thermogenesis. So the results of this experiment further add to the promise of curcumin as an anti-obesity and anti-cellulite natural chemical.

[Source: Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way]

 

 

3/ Curcumin protects fat cells from hypoxia-induced inflammation and insulin resistance...

...via reducing inflammatory adipokine NF-kB and boosting adiponectin secretion. The researchers noted that hypoxia effects huge increases in basal adipocyte glucose uptake (3.3x), leptin (3x), resisting (6.8x) and TLR-4 (8.8x) and reduces adiponectin by reduced adiponectin by 66%.

[Source: Development of insulin resistance through sprouting of inflammatory markers during hypoxia in 3T3-L1 adipocytes and amelioration with curcumin]

 

 

2/ Curcumin PREVENTS MITOCHONDRIAl-dysfunction RELATED disease by...

...protecting mitochondria from oxidation; helping regulate mitochondrial metabolism; modulating cell death due to mitochondrial dysfunction

[Source: Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease]

 

 

1/ Curcumin blocks the growth of new fat cells [in-vivo study]

This new study shows that curcumin represses the differentiation of adipocytes by inhibiting the protein miR-17-5p and by stimulating the Wnt signalling pathway, which is known to inhibit adipocyte growth. This is in addition to multiple other studies which show the anti-adipogenic and/or lipolytic potential of curcumin

[Source: Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2]

 


curcumin protects fat cells from inflammation, helps fight cellulite

  • Dietary phytochemicals called polyphenols are known potent antioxidants that protect body tissues from free radical damage and consequent inflammation.
  • Inflammation and oxidative damage are key components of cellulite, as well as diabetes and several other so-called civilisation diseases, such as heart disease and arthritis.
  • Recent research has now looked into 28 polyphenols (such as hesperidin, resveratrol, epigallocatechin gallate and curcumin) and concluded that those polyphenols protect fat cells from both oxidative damage and inflammation, by reducing inflammatory hormones, such as IL-6.
  • This practically means that orally taken polyphenols (either as foods or as supplements) can be used in the fight against fat tissue inflammation for the prevention of diabetes and cellulite.
  • Polyphenols may also be used with local application in the fight against cellulite as active ingredients in an anti-cellulite cream. Naturally, the more of those polyphenols are present in the cream the better results are to be expected, due to a synergistic effect of using multiple ingredients.
  • Source: Evaluation of antioxidant properties of major dietary polyphenols and their protective effect on 3T3-L1 preadipocytes and red blood cells exposed to oxidative stress
  • Abstract: "Obesity has been associated with a marked risk of metabolic diseases and requires therapeutic strategies. Changes in redox status with increased oxidative stress in adipose tissue have been linked with obesity-related disorders. Thus, the biological effect of antioxidants such as polyphenols is of high interest. We aimed to measure antioxidant capacities of 28 polyphenols representative of main dietary phenolic acids, flavonoids, stilbenes and curcuminoids. Then, 14 molecules were selected for the evaluation of their effect on 3T3-L1 preadipocytes and human red blood cells exposed to oxidative stress. Analysis of reducing and free radical-scavenging capacities of compounds revealed antioxidant properties related to their structure, with higher activities for flavonoids such as quercetin and epicatechin. Their effects on preadipocytes' viability also depended on their structure, dose and time of exposure. Interestingly, most of the compounds exhibited a protective effect on preadipocytes exposed to oxidative stress, by reversing H₂O₂-induced anti-proliferative action and reactive oxygen species production. Polyphenols also exerted an anti-inflammatory effect on preadipocytes exposed to H₂O₂ by reducing IL-6 secretion. Importantly, such antioxidant and anti-inflammatory effects were observed in co-exposition (polyphenol and prooxidant during 24 h) or pretreatment (polyphenol during 24 h, then prooxidant for 24 h) conditions. Moreover, compounds protected erythrocytes from AAPH radical-induced lysis. Finally, these results led to demonstrate that antioxidant and anti-inflammatory properties of polyphenols may depend on structure, dose, time of exposure and cell conditioning with oxidative stress. Such findings should be considered for a better understanding of polyphenols' benefits in strategies aiming to prevent obesity-related diseases."