Genistein and diadzein reduce adipogenesis
Soya isoflavones well known for their effects against fat deposition. Now researcers at Seoul National University have described how genistein and diadzein, the two most improtant soya phytoestrogens (plant estrogens), inhibit adipogenesis (fat cell growth), in vitro.
The researchers found that genistein reduces the differentiation of pre-adipocytes (immature fat cells) into mature adipocytes via an estrogen-related pathway. On the other hand, daidzein exerts it's anti-adipogenic and anti-obesity effects by stimulating lipolysis, i.e. fat release from the fat cells. Both inhibited the expression of adipogenic chemicals, such as PPAR-gamma.
Genistein and diadzein: ideal anti-cellulite ingredients?
Genistein and diadzein possess a mild estrogenic activity, but in contrast to estrogen, they inhibit fat cell growth and reduce several adipogenic (fat growth) markers. This makes them ideal candidates as ingredients in anti-cellulite creams.
- Journal: Cell Proliferation
- Article: Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis
- Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2184.2010.00709.x/abstract
- Excerpt: "Unlike genistein, daidzein inhibited adipogenesis through stimulation of lipolysis, with for example, PKA-mediated hormone sensitive lipase. This is consistent with the increase in glycerol released from AD-MSCs. In conclusion, understanding that different sets of mechanisms of the two isoflavones on adipogenesis will help the design of novel strategies to prevent observed current epidemic levels of obesity, using isoflavones."