- Centella asiatica / gotu kola is well established as a potent natural active for skin firming / skin repair.
- The main active chemicals in centella asiatica extract are the triterpenes madecassoside, asiaticoside, madecassic acid and asiatic acid.
- In this study it was found that gotu kola extract comprising the above phytochemicals significantly stimulated collagen synthesis (better than vitamin C) and lipolysis (better than that of caffeine), and exhibited potent antioxidant / free radical scavenging activity (equal to that of grape seed extract) and protection from UVB damage.
- The sum of all these properites determined in this study (antioxidant, firming, lipolytic) and others determined in other studies (anti-glycation, skin restructuring) make centella / gotu kola the ideal anti-cellulite active for use in anti-cellulite creams also nutritional supplements.
- Source: Triterpene Composition and Bioactivities of Centella asiatica
- Abstract: Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection capacity properties. Triterpenes of Centella were measured using HPLC- PAD on an Excil ODS 5 μm (C18) column for the simultaneous determination of asiatic acid, madecassic acid, asiaticoside and madecassoside. Centella was found to contain significant amounts of madecassoside (3.10 ± 4.58 mg/mL) and asiaticoside (1.97 ± 2.65 mg/mL), but was low in asiatic and madecassic acid. The highest collagen synthesis was found at 50 mg/mL of Centella extracts. The antioxidant activity of Centella (84%) was compared to grape seed extract (83%) and Vitamin C (88%). Its lipolytic activity was observed by the release of glycerol (115.9 μmol/L) at 0.02% concentration. Centella extracts exhibited similar UV protection effect to OMC at 10% concentration. In view of these results, the potential application of Centella in food and pharmaceutical industries is now widely open.
- Centella extract exhibited several potential bioactivities which could be of potential commercial interest in the food and pharmaceutical industries. Evaluation on Centella has found its chemical composition consist of four triterpenes, namely madecassoside, asiaticoside, madecassic acid and asiatic acid. The extract significantly stimulated collagen synthesis, better than vitamin C, and the lipolysis activity was found to be better than that of caffeine. The extract also showed an inhibitory effect with regards to free radical scavenging activity, comparable to grape seed extract. This preliminary UV study suggested that the Centella extract could be a potential natural protection against UVB damage and this activity might be due to its triterpene component(s). Therefore, further experiments are required to identify the component(s) responsible.
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