The olive extract maslinic acid fights fat accumulation

  • The olive extract maslinic acid has been found in a recent study to fight fat accumulation in fat cells, by blocking the protein PPAR-gamma, one of the most important adipogenic proteins in the body
  • Maslinic acid is found in olives and commercially it is extracted from the olive pomace, i.e. the paste that remains after the extraction of extra virgin olive oil from olives.
  • Due to it's anti-adipogenic action, maslinic acid may be useful in the fight against metabolic imbalance, oversight and obesity, and may be also useful in the fight against cellulite as an anti-cellulite cream active ingredient.
  • Source: Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea.
  • Abstract: BACKGROUND: Metabolic syndrome is a set of pathologies among which stand out the obesity, which is related to the lipid droplet accumulation and changes to cellular morphology regulated by several molecules and transcription factors. Maslinic acid (MA) is a natural product with demonstrated pharmacological functions including anti-inflammation, anti-tumor and anti-oxidation, among others. PURPOSE: Here we report the effects of MA on the adipogenesis process in 3T3-L1 cells. METHODS: Cell viability, glucose uptake, cytoplasmic triglyceride droplets, triglycerides quantification, gene transcription factors such as peroxisome proliferator-activated receptor γ (PPARγ) and adipocyte fatty acid-binding protein (aP2) and intracellular Ca(2+) levels were determined in pre-adipocytes and adipocytes of 3T3-L1 cells. RESULTS: MA increased glucose uptake. MA also decreased lipid droplets and triglyceride levels, which is in concordance with the down-regulation of PPARγ and aP2. Finally, MA increased the intracellular Ca(2+) concentration, which could also be involved in the demonstrated antiadipogenic effect of this triterpene. CONCLUSION: MA has been demonstrated as potential antiadipogenic compound in 3T3-L1 cells.