The gene that makes you look 2 years younger

The gene of youth?

After studying thousands of genes on thousands of people, researchers in Holland have found that the carriers of a specific subtype of the gene MC1R look an average of two years younger than their biological age.

MC1R (melanocortin 1 receptor) controls the protein that converts inactive yellow/red melanin to brown/black melanin and leads to tanning, but the authors of the study have stated that the results are independent of skin colour or indeed "age, sex and sun damage (wrinkling, pigmented spots) and persisted through different sun-exposure levels".

Two years is not an enormous difference. Many people look a decade or more younger than their biological age, especially oriental and black people, and definitely there are dozens of other factors at play.

Nevertheless, this is still a beginning in identifying ways to boost youthfulness and beauty based on information gleaned from genetics.



  • Paper: The MC1R Gene and Youthful Looks
  • Abstract: Looking young for one's age has been a desire since time immemorial. This desire is attributable to the belief that appearance reflects health and fecundity. Indeed, perceived age predicts survival [1] and associates with molecular markers of aging such as telomere length [2]. Understanding the underlying molecular biology of perceived age is vital for identifying new aging therapies among other purposes, but studies are lacking thus far. As a first attempt, we performed genome-wide association studies (GWASs) of perceived facial age and wrinkling estimated from digital facial images by analyzing over eight million SNPs in 2,693 elderly Dutch Europeans from the Rotterdam Study. The strongest genetic associations with perceived facial age were found for multiple SNPs in the MC1R gene (p < 1 × 10(-7)). This effect was enhanced for a compound heterozygosity marker constructed from four pre-selected functional MC1R SNPs (p = 2.69 × 10(-12)), which was replicated in 599 Dutch Europeans from the Leiden Longevity Study (p = 0.042) and in 1,173 Europeans of the TwinsUK Study (p = 3 × 10(-3)). Individuals carrying the homozygote MC1R risk haplotype looked on average up to 2 years older than non-carriers. This association was independent of age, sex, skin color, and sun damage (wrinkling, pigmented spots) and persisted through different sun-exposure levels. Hence, a role for MC1R in youthful looks independent of its known melanin synthesis function is suggested. Our study uncovers the first genetic evidence explaining why some people look older for their age and provides new leads for further investigating the biological basis of how old or young people look.