The black grape extract resveratrol protects against blood vessel damage and atherosclerosis in heart disease patients

  • Resveratrol is a natural chemical found in red/black grapes, berry fruit and red wine, and is considered as one of the reasons behind the "French paradox", i.e. the reduced incidence of cardiovascular disease in France, despite high fat consumption (garlic being the other).
  • Indeed, resveratrol has been found in this recently published research paper to be effective in reducing the inflammatory protein TNF-alpha in blood vessels of coronary artery disease patients with angina
  • Resveratrol also reduced the number of blood vessel inner wall particles in the bloodstream, demonstrating a reduction in endothelial (inner wall) damage.
  • The citrus extract quercetin, which also has blood vessel wall protective properties, did not show to have a similar effect against TNF-alpha
  • The amount of resveratrol used in this clinical trial on 93 patients was 100mg/day, which is a modest nutritional supplementation amount
  • Several brands offer 100mg supplements with high quality resveratrol at reasonable prices, so it is easy to benefit from this natural chemical, in an economic fashion (always please ask doctor's approval first)
  • On the other hand, it is very difficult to receive this amount just by eating berries and grapes, and of course we would not recommend consuming 50 litres of pinot noir a day (2mg/lt) or 10 litres of selected Spanish wines / grape juice (10mg/lt) to achieve that amount.
  • In addition to it's cardio protective action, resveratrol is an important, widely researched anti-ageing molecule which is also used in high quality anti-ageing and anti-cellulite creams
  • Source: Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease.
  • Abstract: INTRODUCTION: Endothelial dysfunction (ED) is one of the most important links in the pathogenesis of atherosclerosis (ASVD) - morphological basis of coronary artery disease (CAD). OBJECTIVE: to study the effect of polyphenolic antioxidants, resveratrol and quercetin, on endothelial degeneration factors in CAD patients. MATERIALS AND METHODS: The study involved 93 patients with coronary artery disease: stable angina pectoris, FC II. The cytofluorometric technique was applied to define the level of circulating endothelial microparticles (EMP) CD32+CD40+ in peripheral blood in order to identify ED. The content of tumor necrosis factor α (TNF-α), fibrinogen, hemocoagulation and lipid profile parameters were being determined in the blood, as well. Patients were divided into 3 groups. Basic therapy (β-blockers, statins, aspirin) was prescribed to 33 persons of the comparison group, patients of the study group 1 (30 persons) additionally received resveratrol at a dose of 100 mg daily, patients of the study group 2 (30 persons) got quercetin at a dose of 3 g per day. In 2 months, the second examination of the patients was performed in the amount indicated. RESULTS: under the influence of resveratrol a significant reduction of the level of TNF-α and the number of EMP in peripheral blood was shown, in contrast to the results of other study groups. All groups showed a decrease in total cholesterol and low-density lipoprotein cholesterol, statistical differences between data of groups were not found. Indicators of coagulogramma in all study groups did not change significantly, however, there was a statistically significant reduction of fibrinogen in the blood. CONCLUSIONS: Resveratrol, unlike quercetin, has a positive effect on the endothelial function and systemic inflammation, which may be the result of its influence on intracellular molecular cascades associated with the nuclear transcription factor of NF-kB.

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