Rutin inhibits fat cell growth by blocking multiple fat growth factors (PPAR-gamma, FABP, FAS, lipin1 and C/EBP)

  • The flavonoid rutin, a chemical relative to quercetin, has been found to inhibit adipose tissue growth and expansion, by blocking multiple fat tissue growth factors (PPAR-gamma, FABP, FAS, lipin1 and C/EBP), showing another mechanism by which rutin can fight cellulite
  • The other mechanism is of course the action of rutin against water retention, by protecting capillaries, larger blood vessels and microcirculation, in general.
  • For these reasons, rutin is an ideal natural active in cellulite creams
  • Source: Lipin1-Mediated Repression of Adipogenesis by Rutin.
  • Abstract: Rutin, also called rutoside or quercetin-3-O-rutinoside and sophorin, is a glycoside between the flavonol quercetin and the disaccharide rutinose. Although many effects of rutin have been reported in vitro and in vivo, the anti-adipogenic effects of rutin have not been fully reported. The aim of this study was to confirm how rutin regulates adipocyte related factors. In this study, rutin decreased the expressions of adipogenesis-related genes, including peroxisome proliferators, activated receptor [Formula: see text] (PPAR[Formula: see text], CCAAT/enhancer-binding protein [Formula: see text] (C/EBP[Formula: see text], fatty acid synthase, adipocyte fatty acid-binding protein, and lipoprotein lipase in 3T3-L1 cells. Rutin also repressed the expression of lipin1, which is an upstream regulator that controls PPAR[Formula: see text] and C/EBP[Formula: see text]. In addition, when 3T3-L1 was transfected with lipin1 siRNA to block lipin1 function, rutin did not affect the expressions of PPAR[Formula: see text] and C/EBP[Formula: see text]. These results suggest that rutin has an anti-adipogenic effect that acts through the suppression of lipin1, as well as PPAR and C/EBP.

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