- Ruscogenin, first isolated from the plant Ruscus aculeatus (butcher's broom), is well known - and has been used for centuries - for it's circulation and vein enhancing properties.
- Ruscogenin is also found in the traditional Chinese herb Radix Ophiopogon Japonicus.
- Previous studies have found ruscogenin to fight inflammation and blood clotting (thrombosis), which partially explain it's effectiveness (ruscogenin also enhancing the action of adrenalin on small blood vessels).
- In this study scientists have shown that ruscogenin inhibits endothelial responses to inflammatory hormones / cytokines, such as TNF-alpha, produced during vascular diseases, such as phlebitis, varicose veins and chronic venous insufficiency.
- This explains ruscogenin's anti-inflammatory and anti-thrombotic action on veins and goes to show that ruscogenin is an important ingredient for circulation-enhancing and anti-cellulite creams (poor circulation is an important aspect of cellulite).
- Source: Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB.
- Abstract: "Ruscogenin (RUS), first isolated from Ruscus aculeatus, also a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been found to exert significant anti-inflammatory and anti-thrombotic activities. Our previous studies suggested that ruscogenin remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. Yet the underlying mechanisms remain unclear. In this study, the in vivo effects of ruscogenin on leukocyte migration and celiac prostaglandin E(2) (PGE(2)) level induced by zymosan A were studied in mice. Furthermore, the effects of ruscogenin on TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and nuclear factor-kappaB (NF-kappaB) activation were also investigated under consideration of their key roles in leukocyte recruitment. The results showed that ruscogenin significantly suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, while it had no obvious effect on PGE(2) content in peritoneal exudant. Ruscogenin also inhibited TNF-alpha-induced over expression of ICAM-1 both at the mRNA and protein levels and suppressed NF-kappaB activation considerably by decreasing NF-kappaB p65 translocation and DNA binding activity. These findings provide some new insights that may explain the possible molecular mechanism of ruscogenin and Radix Ophiopogon japonicus for the inhibition of endothelial responses to cytokines during inflammatory and vascular disorders."
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