Retinol improves sun damage and reduces crow's feet wrinkles & skin pigmentation: one year clinical study

  • Retinol is a widely used natural anti-ageing compound that is used in many anti-ageing and anti-cellulite creams
  • Now, a high quality clinical study on humans published today shows that after one year of use, just 0.1% retinol improved and prevented sun damage, reduced skin pigmentation by 84%, and crow's feet wrinkles by 44%
  • Furthermore, on a separate skin tissue study by the same researchers, it was found that the 0.1% retinol boosts collagen & hyaluronic acid in the skin (of course, for faster results a higher concentration of .5% - the maximum recommended for face creams - would make more sense)
  • This shows the great potential of retinol and similar retinol-like compounds in anti-ageing and skin rejuvenation, as ingredients in creams and electro-mesotherapy products



  • Journal: Journal of drugs in dermatology
  • Paper: One-year Topical Stabilized Retinol Treatment Improves Photodamaged Skin in a Double-blind, Vehicle-controlled Trial.
  • Link:
  • Abstract: Retinol, a precursor of retinoic acid, has great potentials as a topical anti-aging molecule; however, only a handful of clinical investigations have been published to date.<br /> OBJECTIVE: This study aimed to assess the efficacy and safety of 0.1% stabilized retinol on photodamaged skin during a one-year treatment.<BR /> METHODS: The investigation included two 52-week, double-blind, vehicle-controlled studies. In the main study, 62 subjects applied either a stabilized retinol formulation or its vehicle to the full face. A second exploratory study evaluated histological/histochemical markers in 12 subjects after 52 weeks of either retinol or vehicle use on contralateral dorsal forearms.<BR /> RESULTS: The retinol group showed significant photodamage improvement over vehicle at all timepoints during the study. After 52 weeks, retinol had improved crow's feet fine lines by 44%, and mottled pigmentation by 84%, with over 50% of subjects showing +2 grades of improvement in many parameters. Additionally, at week 52, histochemical data confirmed the clinical results, showing increased expression of type I procollagen, hyaluronan, and Ki67 as compared to vehicle<BR /> CONCLUSION: This study confirms that a stabilized retinol (0.1%) formulation can significantly improve the signs of photoaging, and improvements in photodamage continue with prolonged use.<BR /><BR /> <em>J Drugs Dermatol</em>. 2015;14(3):271-276.

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