Resveratrol fights ageing by boosting the activity of SIRT1

  • Resveratrol is a well-known anti-ageing and slimming natural compound and is one of the molecules associated with the anti-ageing effects of red wine (the "French paradox").
  • Now scientists in Hong Kong have found that resveratrol reduces stem cell decline and significantly extends life span in mice suffering from premature ageing (progeria), by helping bind a protein called Lamin A onto SIRT1, the "longevity" gene. By boosting the activity of the longevity gene, resveratrol helps fight ageing.
  • (Stem cells are "baby cells" that can be differentiated to any kind of cell in the body. Their number is reduced in ageing and resveratrol halts that decline, thereby boosting tissue regeneration and ageing. Common food sources of resveratrol include berries, grapes and red wine, among others.)
  • Resveratrol is an ideal anti-ageing and anti-cellulite cream active ingredient. It is more and more widely used as an anti-ageing supplement and is an ideal ingredient in anti-ageing creams.
  • In addition, resveratrol has been shown to halt the growth of new fat cells (adipogenesis), on it's own and when combined with other natural substances, such as the phytoestrogen genistein.
  • Therefore, resveratrol is also effective as an anti-cellulite cream active ingredient.
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/23286696
  • Excerpt: "Resveratrol enhances the binding between SIRT1 and A-type lamins to increase its deacetylase activity. Resveratrol treatment rescues ASC decline, slows down body weight loss, improves trabecular bone structure and mineral density, and significantly extends the life span in Zmpste24/− mice."

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