Resveratrol boosts thermogenic activity in brown fat cells, helps burn fat

  • Resveratrol, found in grapes, berries and red wine, is one of the most important anti-ageing natural chemicals available, and also possesses lipolytic capacity
  • In a new study published recently it was found that resveratrol boosts mitochondrial activity in brown fat cells under a high fat diet
  • Brown fat cells differ from normal white fat cells in that they burn fat in the mitochondria, thereby reducing obesity and it's effects. This is in contrast to white fat cells, which accumulate fat, leading to obesity.
  • Resveratrol was also found to improve insulin sensitivity, a hallmark of diabetes type II
  • This, and many other studies, point to the potential of resveratrol (and it's more bioavailable form, pterostilbene) to help reduce body fat accumulation and it's complications
  • Source: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes.
  • Abstract: BACKGROUND: Resveratrol (RSV) is a polyphenolic phytoalexin that has many effects on metabolic diseases such as diabetes and obesity. Given the importance of brown adipose tissue (BAT) for energy expenditure, we investigated the effects of RSV on brown adipocytes. METHODS: For the in vitro study, interscapular BAT was isolated from 7-week-old male Sprague Dawley rats. For the in vivo study, 7-week-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were divided into four groups and treated for 27 weeks with: standard diet (SD); SD+RSV (10 mg/kg body weight, daily); high fat diet (HFD); HFD+RSV. RSV was provided via oral gavage once daily during the in vivo experiments. RESULTS: RSV treatment of primary cultured brown preadipocytes promoted mitochondrial activity, along with over-expression of estrogen receptor α (ER-α). In OLETF rats, both HFD and RSV treatment increased the weight of BAT and the differentiation of BAT. However, only RSV increased the mitochondrial activity and ER-α expression of BAT in the HFD-fed group. Finally, RSV improved the insulin sensitivity of OLETF rats by increasing the mitochondrial activity of BAT, despite having no effects on white adipocytes and muscles in either diet group. CONCLUSION: RSV could improve insulin resistance, which might be associated with mitochondrial activity of brown adipocyte. Further studies evaluating the activity of RSV for both the differentiation and mitochondrial activity of BAT could be helpful in investigating the effects of RSV on metabolic parameters.

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