Reduce the number of your fat cells with episesamin

  • Episesamin, a compound found in the Japanese spice bush Lindera Obtusiloba (and also in sesame oil), was recently reported to inhibit the creation of new fat cells (adipogenenis).
  • Specifically, episesamin:
    • Inhibited the transformation of stem cells (MSC) into new fat cells (adipocyte differentiation) by blocking the pro-adipogenic ("fattening") protein PPAR-gamma
    • Reduced fat accumulation in existing fat cells
    • Stimulated the early death of fat cells (adipocyte apoptosis)
    • Reduced fat tissue inflammation, by blocking the inflammatory proteins TNF-alpha and LPS
  • In summary, because of it's direct inhibiting action on fat cells - the main culprits of cellulite - episesamin seems to be an ideal candidate as an active ingredient in anti-cellulite creams and spot fat reduction formulations.
  • Source: Article: (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS
  • Abstract: Obesity and its associated health risks still demand for effective therapeutic strategies. Drugs and compositions derived from Oriental medicine such as green tea polyphenols attract growing attention. Previously, an extract from the Japanese spice bush Lindera obtusiloba (L. obtusiloba) traditionally used for treatment of inflammation and prevention of liver damage was shown to inhibit adipogenesis. Aiming for the active principle of this extract (+)-episesamin was identified, isolated and applied in adipogenic research using 3T3-L1 (pre)adipocytes, an established cell line for studying adipogenesis. With an IC50 of 10 μM (+)-episesamin effectively reduced the growth of 3T3-L1 preadipocytes and decreased hormone-induced 3T3-L1 differentiation as shown by reduced accumulation of intracellular lipid droplets and diminished protein expression of GLUT-4 and vascular endothelial growth factor. Mechanistically, the presence of (+)-episesamin during hormone-induced differentiation provoked a reduced phosphorylation of ERK1/2 and β-catenin along with a reduced protein expression of peroxisome proliferator-activated receptor γ and a strongly increased protein expression of iNOS. Treatment of mature adipocytes with (+)-episesamin resulted in a reduction of intracellular stored lipid droplets and induced the proapoptotic enzymes caspases-3/-7. Besides interfering with adipogenesis, (+)-episesamin showed anti-inflammatory activity by counteracting the lipopolysaccharide- and tumor necrosis factor α-induced secretion of interleukin 6 by 3T3-L1 preadipocytes. In conclusion, (+)-episesamin seems to be the active drug in the L. obtusiloba extract being responsible for the inhibition of adipogenesis and, thus, should be evaluated as a novel potential complementary treatment for obesity.