- Comment: The venotonic and circulation-enhancing medication Daflon (450m Diosmin + 50g hesperidin) has been effectively used for decades for the relief of poor circulation and vein disease in general. This new paper shows that just 50mg of Pycnogenol, a branded red pine bark extract, has the same effect of vein ulcer healing and circulation improvement / oedema reduction.
- Source: Effect of Pycnogenol on the Healing of Venous Ulcers.
- Abstract: BACKGROUND: Venous ulcers are common complications of chronic venous insufficiency that result in severe physical and mental suffering to patients. The oral administration of diosmin/hesperidin has been used as adjuvant therapy in the treatment of chronic venous insufficiency. The purpose of this study was to evaluate and compare the effect of pycnogenol and diosmin/hesperidin on the healing of venous ulcers. METHODS: This longitudinal, prospective, randomized clinical trial was conducted with 30 adult patients with venous ulcers from a vascular surgery outpatient clinic of a university hospital. The patients were randomly allocated to two groups: group 1 (n=15) was treated with pycnogenol (50 mg orally, three-times daily), and group 2 (n=15) was treated with diosmin/hesperidin (450/50 mg orally, twice daily). They were assessed every 15 days for 90 days. During follow-up visits, photo-documentation was obtained and the ulcer area and circumference of the affected limb were measured. Friedman's test and the Mann-Whitney test were used to compare ulcer areas and circumference of affected limbs between and within groups at the different time points. The level of significance was set at 5% (P<0.05) for all tests. RESULTS: Both the pycnogenol and diosmin/hesperidin treatments had a similar effect on the healing of venous ulcers and led to a significant decrease in the circumference of affected limbs (P<0.0001). CONCLUSION: The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin.
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