Pterostilbene supplementation fights obesity by boosting the gut bacteria Akkermansia and Odoribacter, known for their strong anti-obesity action

  • Source: Pterostilbene-induced changes in gut microbiota composition in relation to obesity
  • Abstract: SCOPE: Nutritional interventions based on the use of natural bioactive compounds might offer new possibilities for reshaping obesity-associated bacterial dysregulation or dysbiosis and improving health. We evaluated whether pterostilbene supplementation could induce changes in gut microbiota (GM) composition and whether these modifications were associated with improvements in metabolic variables. METHODS AND RESULTS: Zucker (fa/fa) rats were given a standard diet supplemented (n = 10) or not (n = 9) with pterostilbene (15 mg/kg body weight/day) by oral gavage for 6 weeks. Faecal samples at the beginning and at the end of the intervention period were analysed by Illumina Mi-Seq sequencing approach. Pterostilbene exerted protective anti-obesity effects, improved metabolic function (insulin sensitivity) and induced structural changes in GM composition. A decrease in the levels of Firmicutes and an increase in Verrucomicrobia phyla were detected in the pterostilbene-treated group. Bacterial species belonging to genera Akkermansia and Odoribacter were also increased. A strong inverse correlation between Akkermansia muciniphila and body-weight was evidenced. Odoribacter splanchnicus showed a negative correlation with adiposity. CONCLUSION: Pterostilbene modifies intestinal bacteria composition towards a healthier microbial profile and suggests that the anti-obesity effects induced in Zucker rats could be associated with an enrichment of the mucin-degrading bacterial members, namely Akkermansia and Odoribacter genus.

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