Lactobacillus probiotics, combined with ultrasound cavitation treatment, reduce body weight!

  • It is now well known that chronic low grade inflammation contributed obesity and lactobacillus probiotics inhibit weight gain caused by inflammation, by regulating the immune system.
  • On the other hand, ultrasound cavitation treatment is a well-known spot fat reduction technique.
  • In this study, researchers combined ultrasound treatment with probiotic ingestion and found that overall full body weight loss in mice after 8 weeks of treatment was 69% in the ultrasound/lactobacillus group, in comparison to 52% in the lactobacillus-only group and 37% in the ultrasound-only group. So for overall full body weight loss lactobacillus was more effective than ultrasound, and the combination of the two was more effective than each of them separately.
  • On the other hand, on the specific fat tissue where ultrasound cavitation treatment was directly applied, cavitation was clearly superior to lactobacillus bacteria, while the combination of the two was still better than each treatment alone, but only slightly so, showing the superior effectiveness of ultrasound for spot fat removal. The fat tissue thickness after 8 weeks of treatment was as follows:
    • No treatment: 1150 μm
    • Lactobacilli treatment: 1060 (very slight improvement at local level)
    • Ultrasound treatment: 370μm (huge improvement at local level)
    • Ultrasound + lactobacilli treatment: 340μm (small improvement at local level, in relation to ultrasound-only)
    • So in summary, this study showed that lactobacillus probiotics help with whole body fat loss but not local fat loss; that ultrasound helps with local body fat loss but not much for overall fat loss; and that the combination produces maximum results on whole body levels but not much better than ultrasound on local fat tissue. Fat cell size and blood lipids also improved due to the combination treatment.
    • Of course, when it comes to slimming, results in mice are always much more pronounced than in humans, so expectations should be more conservative when it comes to humans. But the overall tendency is correct and it clearly applies to humans. ultrasound cavitation has been effectively used for more than a eat now to reduce local body fat, while probiotics also seem to modestly help with whole body weight loss. Combining the two could help maximise the results of ultrasound cavitation treatment, and most probably that of radiofrequency fat / cellulite treatment too, as they work in the same way.
    • Source: Combining ultrasound and lactobacilli treatment for high-fat-diet-induced obesity in mice
  • Abstract: Chronic systemic lipopolysaccharide-induced inflammation can cause obesity. In animal experiments, lactobacilli have been shown to inhibit obesity by modifying the gut microbiota, controlling inflammation and influencing the associated gene expression. A previous study found that high-fat-diet-induced (HFD) obesity was suppressed by lactobacilli ingestion in rats via the inhibition of parasympathetic nerve activity. This study explored the combined use of lactobacilli ingestion and ultrasound (US) to control body weight and body fat deposition in HFD mice over an 8-week experimental period. Male C57BL/6J mice received an HFD during treatment and were randomly divided into four groups: (i) control group (H), (ii) lactobacilli alone (HB), (iii) US alone (HU) and (iv) lactobacilli combined with US (HUB). The US was targeted at the inguinal portion of the epididymal fat pad on the right side. At the 8th week, body weight had decreased significantly in the HUB group (15.56 ± 1.18%, mean ± SD) group compared with the HU (26.63 ± 0.96%) and H (32.62 ± 5.03%) groups (p < 0.05). High-resolution microcomputed tomography (micro-CT) scans revealed that the reduction in total body fat volume was significantly greater in the HUB group (69%) than in the other two experimental groups (HB, 52%; HU, 37%; p < 0.05). The reductions in the thickness of the subcutaneous epididymal fat pads were significantly greater in the HUB group (final thickness: 340 ± 7 μm) than in the H (final thickness: 1150 ± 21 μm), HB (final thickness: 1060 ± 18 μm) and HU (final thickness: 370 ± 5 μm) groups (all p < 0.05). Combination therapy with lactobacilli and US appears to enhance the reduction in body weight, total and local body fat deposition, adipocyte size and plasma lipid levels over an 8-week period over that achieved with lactobacilli or US alone in HFD mice. These results indicate that US treatment alone can reduce hyperlipidemia in HFD mice.