Poor circulation/oxygen levels boost fat accumulation, fibrosis and cellulite

  • Poor blood microcirculation leads to impaired oxygenation of tissues, a condition called hypoxia
  • Hypoxia is well-known to induce fibrotic changes in tissues, including fat/adipose tissue
  • Adipose tissue fibrosis is a risk factor for metabolic syndrome, diabetes and heart disease, as it increases insulin resistance and chronic, low grade inflammation
  • New research published last week has now shown that not only hypoxia causes fibrosis but it also increases fat accumulation, by inhibiting thermogenesis (thermogenesis is the oxidation of fat in brown fat cells)
  • So poor microcirculation, not only has negative effects on the body due to impaired tissue nourishment and oxygenation, but it also has the previously known secondary side effects of fibrosis, low grade inflammation, and the newly discovered side effect of excess fat accumulation
  • Furthermore, chronic, low grade inflammation, fat accumulation, poor microcirculation and fibrosis are all hallmarks of the aesthetic condition that we call cellulite
  • It is becoming more and more clear that maintaining healthy circulation levels is extremely important for both health and aesthetics reasons
  • Exercise and healthy eating are important in boosting blood circulation and tissue oxygenation, while sedentary living, tight clothes, compression garments/spanx, smoking and sugar/saturated fat intake all inhibit healthy circulation  
  • Supplements such as fish oil, garlic, ginkgo biloba, gotu kola, horse chestnut extract, hesperidin, pine bark extract and cocoa polyphenols are all great ways to further boost microcirculation
  • The same actives (with the exception of fish oil and garlic) are also applied topically (in the form of a cream or as part of an electro-mesotherapy treatment) with the aim to help boost microcirculation and reduce/prevent cellulite
  • Finally, treatments such as strong cellulite/lymphatic stimulation massage, and especially monopolar radiofrequency, are also used to boost microcirculation and fight cellulite at a local level
  • Source: Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.
  • Abstract: Hypoxia-inducible factor-1α (HIF-1α) in adipose tissue is known to promote obesity. We hypothesized that HIF-1α interferes with brown fat thermogenesis, thus decreasing energy expenditure. To test this hypothesis, we compared transgenic mice constitutively expressing HIF-1α in adipose tissues (HIF-1α++) at usual temperature (22 °C), where brown fat is somewhat active, or at thermoneutrality (30 °C), where brown fat is minimally active. HIF-1α++ mice or control litter mates were separated into room temperature (22 °C) or thermoneutrality (30 °C) groups. We assessed weight gain, food intake, calorimetry, activity, and oxygen consumption and transcriptional changes in isolated white and brown adipocytes. At 22 °C, HIF-1α++ mice exhibited accelerated weight gain, cold and glucose intolerance, hyperglycemia, and decreased energy expenditure without changes in food intake or activity. These changes were absent or minimal at thermoneutrality. In brown adipocytes of HIF-1α++ mice, oxygen consumption decreased ~50 % in association with reduced mitochondrial content, uncoupling protein 2, and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1α). In conclusion, adipose HIF-1α overexpression inhibits thermogenesis and cellular respiration in brown adipose tissue, promoting obesity in the setting of reduced ambient temperature. KEY MESSAGE: Constitutive HIF-1α activation in adipose tissue promotes weight gain in mice. The weight gain is associated with reduced brown adipose tissue function and oxygen consumption. Reduced oxygen consumption may be mediated by reductions in mitochondria.

< Back to cellulite