Patient satisfaction with hesperidin, ascorbic acid and ruscogenin for the treatment of chronic venous disease (clinical study)

  • In a study comparing patient satisfaction of different therapies of advanced stage chronic venous disease it was found that of the 780 patients studied, and after six weeks of treatment, 71.3% were satisfied after surgical intervention; 51.4% with a natural vasoactive drug (supplement) consisting of ruscus aculeatus (butcher's broom), HMC (hesperidin) and ascorbic acid (vitamin C); and 43% with compression therapy (pressotherapy / bandaging).
  • In the drug/supplement group,  "out of 377 patients with active venous ulcers smaller than 200 cm2, 18% have been cured, and 66.6% have improved during 6-week period of observation!
  • The researchers concluded that effects exerted on veins, capillaries and lymphatic vessels by the vasoactive supplement/drug explain the positive results observed in this study.
  • All three components of the drug, i.e. ruscus, ascorbic acid and hesperidin are well researched and widely established for their natural and safe vein / circulation / lymphatic drainage supporting action, and they are valuable ingredients, taken either orally (supplements) or locally (creams) in the fight against venous insufficiency, water retention, poor circulation and cellulite.
  • Given that new, more advanced vasoactive supplements exist today, if those newer, more advanced products were used, most probably an even higher number of customer satisfaction would have been recorded.
  • Source: Patients' satisfaction with therapy methods of advanced chronic venous disease.
  • Abstract AIM: To assess patients' satisfaction from the therapy of advanced chronic venous disorders (CVD) in everyday clinical practice in Poland, and to compare the efficacy of various venoactive drugs (VADs) in venous ulcers healing process. METHODS: 780 unselected adult patients with active (N=441) or healed (N=339) venous ulcers participated in the non-interventional observational 6-week study. RESULTS: Compression therapy and VADs were utilized by 81.5% and 89.2% of patients respectively. 31.2% of all patients underwent surgical procedures for vein incompetence, 61.3% were satisfied with surgical methods, 43% with compression therapy, and 32.6% with VADs - with highest rate of satisfied patients in the group taking Ruscus aculeatus and HMC and ascorbic acid (51.4%). Of 377 patients with active venous ulcers smaller than 200 cm2, adherent to VADs, 18.0% have been cured, and 66.6% have improved during 6-week period of observation. Multiple logistic regression analysis revealed that the compression therapy [OR=2.74], the size of ulcer ≤ 10 cm2 [OR=2.70] were increasing the change of ulcer healing. No VADs was better than another in the healing process. CONCLUSIONS: 1) Compression therapy and VADs are highly utilized by patients with advanced CVD. 2) Patients are more satisfied with surgical than conservative treatment of advanced CVD. 3) More than half of the patients with the advanced stage CVD taking Ruscus aculeatus and HMC and ascorbic acid is satisfied with the obtained improvement. 4) Ruscus aculeatus and HMC and ascorbic acid is similarly effective as other frequently used VADs in venous ulcer healing. 5. Ruscus aculeatus and HMC and ascorbic acid exerting effects on veins, capillaries and lymphatic vessels may explain the positive results observed in this study.

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