- Comment: Centella asiatica / gotu kola extract is well-known for it's skin whitening properties and this study confirms that madecassoside, one of the 4 main triterpenes in centella "significantly reduces UV-induced melanin index at 8 weeks after topical application". Madecassoside achieves that, at least partially, by blocking multiple markers of inflammation on skin.
- Source: Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation.
- Abstract: Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and anti-aging agent. However, the involvement of MA in skin-pigmentation has not been reported. This study was conducted to investigate the effects of MA on ultraviolet (UV)-induced melanogenesis and mechanisms in a co-culture system of keratinocytes and melanocytes. MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system. These effects were further demonstrated by the MA-induced inhibition of protease-activated receptor-2 expression and its signaling pathway, cyclooxygenase-2, prostaglandin E2 and prostaglandin F2 alpha in keratinocytes. The clinical efficacy of MA was confirmed on artificially tanned human skin. MA significantly reduced UV-induced melanin index at 8 weeks after topical application. Overall, the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.
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