How to help prevent sun damage and ageing by blocking COX-2

  • COX-2 is one of the most common inflammatory enzymes in the body and a recent study has discovered that levels of this enzyme are elevated in collagen cells (fibroblasts) and keratin cells (keratinocytes) of women who had sun damaged skin - these levels were found to be much higher than in women with normal ageing.
  • The authors of the study explain that  "The results indicate that COX-2 (cyclooxygenase-2) may be involved in the pathogenesis of the photoaging process. Inhibition of expression or activity of the enzyme may find application in photoaging treatment and/or prophylaxis."
  • Practically this means that eating foods rich in natural COX-2 blockers, such as oily fish and turmeric, taking fish oil or turmeric food supplements or applying anti-ageing creams rich in boswellia extract or curcumin extract, all of which are known to block COX-2, can help partially prevent sun damage. 
  • Source: Increase in cyclooxygenase-2 (COX-2) expression in keratinocytes and dermal fibroblasts in photoaged skin,