How the fat cell hormone leptin affects breast cancer

  • "More than one million new cases of breast cancer are diagnosed worldwide each year and more than 400,000 deaths are caused by the disease. The origin of this pathology is multifactorial and involved genetic, hormonal, environmental and nutritional factors including obesity in women after menopause. The role played by the adipose tissue and their secretions, ie adipokines, is beginning to be recognised."
  • Fat cells secrete hormones, called adipokines, which can affect breast cells both locally in the breast (breast cells, including breast cancer cells are surrounded by fat cells, especially in obese women) and remotely, via the blood circulation.
  • Leptin, a fat cell hormone whose levels are elevated in obesity or overweight, appears to be strongly involved in breast cancer cell creation (mammary carcinogenesis) and may contribute to inflammation, oxidative damage and cancer cell immunity, especially in obese patients (such patients have increased potential for metastasis and greater risk of death from cancer.
  • Leptin levels are naturally reduced by eating a diet low in sugar, carbs and saturated fat and rich in fruit, vegetables and oily fish, increasing exercise and in general by losing weight and all those measures are also known to contribute in the fight against beast cancer. Several herbal extracts, such as curcumin, EGCG from green tea and dozens others are also known to reduce fat cell inflammation, oxidative stress and also help prevent cancer.
  • Source: Leptin, adipocytes and breast cancer: Focus on inflammation and anti-tumor immunity, http://www.ncbi.nlm.nih.gov/pubmed/25957709