How the centella / gotu kola extract asiaticoside boosts not just skin collagen production but also collagen cell population

  • The centella asiatica (gotu kola) extract asiaticoside, is well-known to promote skin connective tissue repair and wound healing.
  • In a study assessing the exact biology of this action of asiaticoside on skin and connective tissue repair, it was found that asiaticoside affected the expression of 54 genes related to connective tissue function!
  • Specifically, asiaticoside upregulated the expression of genes related to fibroblast "cell proliferation, cell-cycle progression and synthesis of the extracellular matrix".
  • This, in simple terms, means that collagen cells mature and multiply faster and produce more collagen and other connective tissue proteins.
  • In the same study it was found that asiaticoside boosted the secretion of collagen type I (the hard collagen that gives firmness to skin and connective tissue) and collagen type III (the softer, "baby collagen", which is produced before collagen type I and helps with connective tissue repair and regeneration).
  • Asiaticoside is one of four chemicals, all equally important, that are found in centella asiatica plant and which possess similar connective tissue strengthening and repair action.
  • Because of this action on connective tissue, and also blood circulation, we believe that centella asiatica extract is the most important skin tightening an anti-cellulite active for use in cellulite creams and also in nutritional supplements to support connective tissue and help prevent cellulite.
  • Source: Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts.
  • Abstract: Asiaticoside, isolated from Centella asiatica, promotes fibroblast proliferation and extracullar matrix synthesis in wound healing. The precise mechanism, however, in molecular and gene expression levels still remains partially understood. Using cDNA microarray technology, the alternation of genes expression profiles was determined in a human dermal fibroblast in vitro in the presence of asiaticoside (30 microg/ml). Fifty-four genes, with known functions for cell proliferation, cell-cycle progression and synthesis of the extracellular matrix, were significantly up-regulated in our "whole-genes nest" expression profile at various timepoints. Furthermore, mRNA levels and protein productions of certain genes responsible for extracellular matrix (ECM) synthesis (e.g. encoding type I and type III collagen proteins) were evaluated by Northern blot and radioimmunoassay, respectively. As a result, there is a close correlation among the gene profile, mRNA and protein production in the cells response to asiaticoside stimulation. This information could be used for exploring the target genes in response to asiaticoside in fibroblasts.

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