Raspberry ketone can reduce body fat and cellulite, by boosting norepinephrine induced lipolysis

  • Raspberry ketone (also known as frambinone and rheosmin) is an aromatic compound found all red raspberries (Rubus idaeus) which is extensively used in perfumery. It's chemical structure is similar to that of zingerone, a ginger extract which reduces obesity. It is also similar to that of capsaicin (the chemical that gives hot chili peppers their "burning" quality), to synephrine (a substance found in orange peel and known to help reduce fat and fluid retention) and evodiamine (another fat loss ingredient). All these chemicals, including raspberry ketone, interact with fat cells and induce fat loss via similar mechanisms.
  • In 2004 a group of Japanese researchers examined the anti-obesity action of raspberry ketone in mice. To test the effect on obesity, the researchers fed mice in one experiment a high-fat diet including 0.5, 1, or 2% of raspberry ketone for 10 weeks. In another experiment mice were given a high-fat diet for 6 weeks and then fed the same high-fat diet containing 1% of raspberry ketone for the next 5 weeks.
  • After 11 weeks the results were rather amazing. Raspberry ketone did indeed prevent the high-fat-diet-induced fat gain in the first experiment, and decreased the fat accumulation produced by 6 weeks of high fat diet in the second experiment. In addition, raspberry ketone decreased the amounts of fat accumulated in the liver caused by the high fat diet, thereby improving fatty liver. The researchers concluded that this obesity preventing and reducing effect was due to the potentiation of the norepinephrine-induced lipolysis (i.e. fat breakdown) in fat cells.
  • Norepinephrine is produced by the body when we exercise, therefore the best time to consume raspberries or apply a raspberry ketone-rich cellulite cream on areas with excess fat, is immediately before and/or after exercise. This is when the raspberry ketone can really perform it’s magic.
  • In addition to raspberry ketone, raspberries and other berry fruits contain several other substances that help prevent and improve various health conditions, as well as overweight, cellulite, skin looseness and fluid retention, and are one of the most healthful foods you can eat. They offer lots of fibre and antioxidants and very few calories, making them very "dense" nutritionally.
  • You may literally consume as many fresh berries as you wish without fearing weight gain. In fact by doing so you will lose weight, because you will eat less of the calorie-dense foods that lead to fat accumulation and stop you from losing weight. The same principle applies to green vegetables, with the only difference that green vegetables are even better than berries as they contain almost no calories at all.
  • In addition to eating lots of berry fruits you may use raspberry ketone in a different way: by applying it on your skin in the form of a raspberry ketone-rich cellulite cream, immediately before or after exercise when noradrenaline (a.k.a. norepinephrine) levels are high.
  • However, you should know that food must not be eaten up to three hours before exercise as the anti-lipolytic effect of insulin will negate any benefits raspberry ketone and exercise have to offer. Food consumption immediately after one hour or more of vigorous exercise is absolutely fine and will not reduce the results of either exercise or raspberry ketone.
  • Source: Anti-obese action of raspberry ketone
  • Link: http://www.sciencedirect.com/science/article/pii/S0024320505001281
  • Excerpt: "Raspberry ketone (4-(4-hydroxyphenyl) butan-2-one; RK) is a major aromatic compound of red raspberry (Rubus idaeus). The structure of RK is similar to the structures of capsaicin and synephrine, compounds known to exert anti-obese actions and alter the lipid metabolism. The present study was performed to clarify whether RK helps prevent obesity and activate lipid metabolism in rodents. To test the effect on obesity, our group designed the following in vivo experiments: 1) mice were fed a high-fat diet including 0.5, 1, or 2% of RK for 10 weeks; 2) mice were given a high-fat diet for 6 weeks and subsequently fed the same high-fat diet containing1% RK for the next 5 weeks. RK prevented the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose tissues (epididymal, retroperitoneal, and mesenteric). RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet. RK significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase from the cytosol to lipid droplets in rat epididymal fat cells. In conclusion, RK prevents and improves obesity and fatty liver. These effects appear to stem from the action of RK in altering the lipid metabolism, or more specifically, in increasing norepinephrine-induced lipolysis in white adipocytes."

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