How low molecular weight hyaluronic acid can reduce fat and fight obesity

  • Hyaluronic acid is now well-known for it's skin moisturising, joint lubricating and anti-ageing benefits. However, what is not known that depending on the size of the hyaluronan molecule, it can have different effects on the body.
  • Low molecular weight hyaluronic acid of around 50,000 Dalton (50kDa) size is already known to inhibit fat cell growth in the lab
  • Now a new study has shown that oral ingestion of such hyaluronic acid actually decreases body weight, fat tissues, LDL cholesterol triglycerides, leptin fatty liver in mice, indicating a direct anti-obesity effect.
  • The researchers have found that 50kDa hyaluronate inhibits the proteins PPAR-gamma and FAS, which have a "fattening" effect and boosts UCP2 and PPAR-alpha, which have a "slimming" effect.
  • This anti-adipogenic effect on fat cells means that low molecular weight hyaluronic acid may be an ideal ingredient for anti-cellulite creams
  • Source: Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice.
  • Abstract: Hyaluronan has diverse biological activities depending on its molecular size. The hyaluronan fragments (50 kDa) can decrease adipogenic differentiation in vitro. However, in vivo anti-obesitic effects of hyaluronan fragments have not been elucidated. Therefore, we examined the anti-obesity effects of hyaluronan fragments on high-fat diet induced obesity in in C57BL/6 mice. Oral administration of hyaluronan fragments (200mg/kg for 8 weeks) decreased body weight, adipose tissues, serum lipid (low-density lipoprotein cholesterol, triglyceride), and leptin level. Hyaluronan fragments decreased the hypertrophy of adipose tissue and ameliorated liver steatosis. The mRNA expression of leptin was reduced in adipocyte by treatment with hyaluronan fragments. Additionally, hyaluronan fragments enhanced the mRNA expression of PPAR-α and its target genes UCP-2 and decreased mRNA expression of PPAR- γ and fatty acid synthase in liver. In conclusions, hyaluronan fragments had marked effects on inhibiting the development of obesity in obese mice fed the high-fat diet. It suggested that enhancing PPAR-α and suppressing PPAR-γ expression are two possible mechanisms for the anti-obesitic effect of hyaluronan fragments.

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