Forskolin stimulates fat release as potently as adrenergic stimulation, with the combination of both producing maximum results

  • Forskolin is a natural chemical which is used as supplement and cellulite cream ingredient for it's lipolytic (fat releasing) action on fat cells.
  • In this study forskolin was found to stimulate lipolysis as well as an adrenaline / noradrenaline analog, but it stimulates the production of 10 times more cAMP in the cell (cAMP stimulates energy production / fat burning in fat cells and vasodilation in blood vessels).
  • Adrenaline and noradrenaline are produced during exercise and are the most potent fat release chemicals in the body, so forskolin has a similar effect on fat cells as exercise.
  • On the other hand, in the same study it was shown that forskolin's fat release effect was potentiated by:
    • the adrenaline / noradrenaline analog (so we should practically expect that forskolin + exercise would have even stronger lipolytic effect than either exercise or forskolin alone)
    • an adenosine inhibitor (so we should practically expect that forskolin + caffeine would have even stronger lipolytic effect than either caffeine or forskolin alone)
  • In practice, the results of this and other similar studies show that forskolin works better when combined with caffeine (an adenosine inhibitor), and these two ingredients should be together in anti-cellulite creams and for spot fat reduction treatments / creams.
  • Furthermore, exercise (an adrenaline / noradrenaline stimulator) could potentially maximise the effect of forskolin, or forskolin combined with caffeine.
  • Source: Stimulation of cAMP accumulation and lipolysis in hamster adipocytes with forskolin.
  • Abstract: This study compares the effects of forskolin and isoproterenol on lipolysis and adenosine 3',5'-cyclic monophosphate (cAMP) accumulation in hamster white adipocytes. Rates of lipolysis in forskolin-stimulated cells were equivalent to those in cells incubated with isoproterenol, but cAMP levels were more than 10-fold greater in the presence of forskolin. The stimulatory effects of forskolin were partially inhibited by N6-phenylisopropyl adenosine but not by 2',5'-dideoxyadenosine. In other experiments, cells were exposed to forskolin in combination with either isoproterenol or adenosine deaminase. A concentration of forskolin that caused only a small increase in lipolysis was used. When isoproterenol or adenosine deaminase were added with forskolin, lipolysis increased dramatically, but cAMP content either did not change, as occurred with isoproterenol, or increased only slightly with adenosine deaminase. Isoproterenol potentiation of forskolin's lipolytic action persisted in the absence of extracellular K+, even though the lipolytic response to isoproterenol alone was absent in K+-free media. These data demonstrate that the lipolytic responses of adipose tissue are more complex than are responses simply in proportion to cellular concentration of cAMP. Such complexity could arise if lipolytic regulatory factors other than cAMP existed or if cAMP and protein kinase were functionally segregated within adipocytes.

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