How escin improves vein tone, blood circulation, water retention and oedema and fights cellulite

  • Escin (aescin) is one of the three actives contained in horse chestnut (Aesculus hippocastanum) extract responsible for it's well-known action on chronic venous insufficiency (clinical water retention / oedema), haemorrhoids, post-operative oedema and cellulite (water retention is an important aspect of cellulite).
  • Chronic venous insufficiency is a disease from which "10–15% of adult men and 20–25% of women suffer. It reflects more than a ‘cosmetic problem’ because many patients require hospital and/or surgical  treatment and this disease leads to a high degree of suffering and a high economic cost for society".
  • Furthermore, cellulite affects more than 80% of women above the age of 30 and although cellulite is only a cosmetic condition, the majority of women seek solutions on how to prevent or reduce it.
  • There is plenty of scientific literature supporting the effectiveness and safety of escin, one of which found it has the same efficacy in oedema as compression therapy, after just 8 weeks of treatment - without the inconvenience of compression bandages / garments.
  • In another double-blind, placebo-controlled study "oral treatment for 2–8 weeks with 100-150mg/day of escin led to a significant reduction in leg volume and symptoms (pain, fatigue, sensation of tension, itching) compared to placebo."
  • Additionally, escin is very well tolerated and has been used in massive studies with tens thousands of patients with excellent results and safety. 
  • According to a review of all the major research papers on escin, this natural chemical possesses "clearcut anti-oedematous, anti-inflammatory and venotonic properties" via a "wide ranging mechanism of therapeutic activity".
  • Specifically, escin allows improved response to calcium ions which raises venous tension and contractions (i.e. better vein tone); it releases the prostaglandine PGF2-alpha from veins; it antagonises histamine; it prevents leukocyte activation / inflammation and prevents hypoxia-related reactions, such as reduction in cell energy levels / ATP.
  • Escin also inhibits the enzymes elastase and hyaluronidase and thereby protects elastin and hyaluronic acid from damage. As a result, blood vessels are "sealed", preventing the leakage of water into the tissues and the consequent water retention / oedema.
  • In summary, escin is a valuable, safe and effective natural vein-toning and circulation-enhancing active against water retention, oedema and cellulite. Creams with a high concentration of purified escin, especially in combination with esculoside and proanthocyanidin (the other two actives in horse chestnut) and with other synergistic actives, can provide valuable help with cellulite, heavy / painful / tense legs and water retention.
  • Source: Aescin: pharmacology, pharmacokinetics and therapeutic profile, http://www.ncbi.nlm.nih.gov/pubmed/11529685
  • Excerpt: "In inflammatory conditions, as well as during blood stasis, resulting in decreased oxygen supply, a reduction in ATP content may occur due to lowered mitochondrial oxidative phosphorylation. This results in a cascade of metabolic events: release of prostaglandins and PAF, neutrophil recruitment, adherence and activation, all leading to venous stasis and oedema in the case of varicose disease. Aescin can well antagonize the reduction in ATP content and increased phospholipase A2 responsible for the release of precursors of inflammatory mediators. There is, furthermore, a reduced neutrophil adherence/activation, all resulting in the protection of veins and reduced oedema... The therapeutic efficacy, as shown in the international literature, includes studies published in top ranked journals, and is well supported by a large number of randomized controlled studies. In one trial aescin was shown to be as effective as compression therapy as an alternative to medical treatment for CVI."

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