How centella asiatica protects veins from damage after deep vein thrombosis

  • Gotu kola / centella asiatica is well known for it's connective tissue repair and vein protective action. In fact, one reason centella asiatica protects blood vessels is by maintaining blood vessel connective tissue integrity.
  • Patients who suffer from phlebitis (vein inflammation), chronic deep vein thrombosis and especially post-thrombotic syndrome have "an increased number of circulating endothelial cells in comparison to normal subjects (3.8 cells versus 1.5, per counting chamber)".
  • Basically, in the post-phlebitic syndrome, endothelial cells, i.e. cells that line the inside of blood vessels get unattached from the blood vessels and are shed into the blood stream. Endothelial cells normally line blood vessels to maintain vascular integrity and permeability, but when these cells enter into the circulation, this is a reflection of vascular damage.
  • By preserving the integrity of the connective tissue to which endothelial cells are attached, centella asiatica should reduce endothelial cell shedding.
  • In a study assessing the effectiveness of concentrated gotu kola extract, containing only triterpenes (such as asiatic acid, madecassic acid and asiaticoside), it was found that treatment for three weeks with this extract caused a statistically significant reduction of circulating endothelial cells (1.80 cells per counting chamber), bringing endothelial cells to almost normal levels.
  • Clearly centella asiatica triterpenes are ideal for the complementary treatment of vascular disorders, especially when combined with similar vasoprotective actives, such as ruscogenin, hesperidin, escin and esculoside, among others.
  • Given that vascular integrity and good circulation are important in preventing water retention and cellulite, gotu kola / centella asiatica triterpenes are ideal natural actives for creams against cellulite and puffiness / water retention.
  • Source: Centella Asiatica Triterpenic Fraction (CATTF) reduces the number of circulating endothelial cells in subjects with post phlebitic syndrome.
  • Abstract: Here we report a study performed in order to assess the number of circulating endothelial cells (EC) in normal subjects and in patients with post-phlebitic syndrome (PPS), and the effect of treatment with Centella Asiatica Triterpenic Fraction (CATTF), a drug which has been demonstrated to be effective in promoting wound healing in vivo. EC counts were determined by means of differential centrifugation and phase contrast microscopy. Patients with PPS showed an increased number of circulating EC in comparison to normal subjects (3.8 +/- 1.2 cells versus 1.5 +/- 0.6 per counting chamber). Treatment for three weeks with CATTF caused a statistically significant reduction of circulating EC (1.80 +/- 0.6 cells per counting chamber).

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