How ayurvedic herbal extract bakuchiol boosts collagen production and helps prevent ageing

  • Bakuchiol, an extract of the important ayurvedic herb Psoralea corylifolia (Babchi), is a well-known anti-ageing compound with retinol-like anti-ageing and anti-acne properties, without the irritating side-effects of retinol.
  • Now, in a recently published study, bakuchiol was found to enhance collagen and elastin production by stimulating fibroblasts (collagen cells) and by inhibiting the breakdown of those two important skin proteins by MMPs (MMPs or matrix metalloproteinases are enzymes that break down collagen and elastin, thereby causing skin thinness, lack of elasticity and overall skin aging.
  • Collagen and elastin are the two most important skin proteins and are responsible for the skin's firmness and elasticity, respectively. By boosting collagen and elastin production and by preventing their damage, bakuchiol helps prevent skin ageing and is thereby an important natural ingredient for anti-ageing creams.
  • Source: Regulative effect of bakuchiol on ESF-1 cells anti-aging gene
  • Abstract: OBJECTIVE: To explore the mechanism of bakuchiol on anti-aging gene mRNA expression level of human skin fibroblasts (ESF-1). METHODS: The potential of cell proliferation which was divided into blank group,positive control estradiol group, and bakuchiol high, medium and low dose groups was detected by MTT. The expression levels of Col I, Col III, TIMP-1, TIMP-2 and MMP-1 mRNA were detected with RT-PCR. RESULTS: ESF-1 vitality and the expression levels of Col I, Col III, TIMP-1 and TIMP-2 mRNA were significantly increased by bakuchiol and E2. However, the expression of MMP-1 mRNA was reduced by bakuchiol and E2. CONCLUSION: The bakuchiol can enhance ESF-1 cell activity, promote collagen and matrix metalloproteinase inhibitors mRNA expression level and inhibit mRNA expression of matrix metalloproteinases in order to postpone skin aging.