- In this study it was found that the titrated extract of the indian herb Gotu kola / Centella asiatica (TECA) reduces the melanin content in melanocytes by inhibiting tyrosinase. A specific active found in TECA, asiaticoside, may have beneficial effects in hyperpigmentation diseases or for skin whitening".
- So centella, in addition to it's skin repair / skin tightening action, has a pronounced skin whitening effect, which is useful for pigmentation disorders.
- Source: Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.
- Abstract: Melanogenesis is the process of generating pigmentation via melanin synthesis and delivery. Three key enzymes, tyrosinase, tyrosinase-related protein 1 (TRP1) and TRP2, metabolize melanin from L-tyrosine. Melanin synthesizing enzymes are regulated by microphthalmia-associated transcription factor (MITF). The titrated extract of Centella asiatica (TECA) contains the major components asiatic acid, asiaticoside and madecassic acid. The present study revealed that TECA reduces the melanin content in melanocytes. Moreover, the asiaticoside contained in TECA modulated melanogenesis by inhibiting tyrosinase mRNA expression. The decrease in tyrosinase mRNA levels was mediated through MITF. Uniquely, asiaticoside inhibited MITF by decreasing its DNA binding affinity. In conclusion, the results of the present study indicate that asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening.
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