- Natural actives, such as horse chestnut extract, flavonoids (such as quercetin, hesperidin and rutin), red vine leaves extract, gotu kola / centella asiatica extract and proanthocyanidin, on their own or in combination with compression garments, can offer valuable help in cases of chronic venous insufficiency, lymphedema and circulation impairment, according to this study.
- These actives have been used orally and topically for decades for these purposes, and can offer valuable help in both skin circulation improvement and cellulite reduction (skin microcirculation impairment is an important factor of cellulite).
- Source: A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options
- Abstract: Impairment of the cutaneous microcirculation is a major predisposing factor in inflammation and ulceration in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate predisposes to the formation of edema. Local lymphedema is a complication of CVI, often underdiagnosed. This review is focused on CVI but excludes the complication of ulceration. Treatment of microcirculatory dysfunction can be done by pharmacologic intervention or compression therapy or using a combination of both. This review is focused on drugs that have been evaluated by randomized prospective controlled trials. The following compounds are discussed: horse chestnut seed extracts, flavonoids, red vine leaves extracts, total triterpenic fraction of Centella asiatica (L), prociadins, calcium dobesilate, and pentoxifylline. The microcirculatory effects of compression therapy using bandages or stockings are also reviewed. The major microcirculatory effects that have been shown are the reduction of capillary filtration rate and improvements in levels of transcutaneous partial pressures of oxygen and carbon dioxide (TcPO(2) and TcPCO(2)). Available data suggest that a combination of pharmacologic and compression therapy may have some additive effects.
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