- Ruscus aculeaus (butcher's broom) extract is well known for it's action on circulation improvement and chronic vein insufficiency. The flavonoid hesperidin and Vitamin C are also well established vein toning natural chemicals.
- In a study asessing the effectiveness of the combination of these three venotonic chemicals, it was found that patients with chronic venous insufficiency that took 2 capsules a day for 60 days, experienced "significant decrease and regression of clinical symptoms and a reduction in lower limb circumference measured at the ankle were observed."
- Ruscogenin and neoruscogenin, found in butcher's broom extract, are important actives against poor circulation and, as expected, work better in combination with other circulation-enhancing actives. Local application, in the form of microcirculation-boosting or anti-cellulite creams and food supplements is warranted.
- Source: A Study of the Efficacy and Tolerability of a Preparation Containing Ruscus aculeatus in the Treatment of Chronic Venous Insufficiency of the Lower Limbs
- Abstract: Objective: The objective of the study was to assess the efficacy and tolerability of an extract of Ruscus aculeatus combined with hesperidin methyl chalcone and ascorbic acid (Cyclo 3 Fort®) in the treatment of uncomplicated chronic venous insufficiency. Design and Methods: A randomised, double-blind, placebo-controlled study was conducted in 60 patients with uncomplicated chronic venous insufficiency. The patients received two daily capsules of a Ruscus extract combination formulation or placebo for a period of 60 days. Results: During the period of treatment with the Ruscus extract combination formulation, a significant decrease and regression of clinical symptoms and a reduction in lower limb circumference measured at the ankle were observed. The overall assessment of efficacy in the 30 patients receiving the active drug combination showed an excellent result in 15 patients, good in 13 and moderate in two. Of the 30 patients receiving placebo, the results were excellent in four, good in 17, moderate in eight and insufficient in one. Tolerability was considered excellent in 23 cases, good in five and poor in two. Conclusion: It was concluded that Ruscus extract combined with hesperidin methyl chalcone and ascorbic acid is effective and well tolerated in the treatment of patients with uncomplicated venous-lymphatic insufficiency of the lower limbs.
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