- This is yet another placebo controlled study to show that centella asiatica / gotu kola extract helps with venous hypertension (high blood pressure in veins) and oedema (water retention reduction).
- In this study 20 patients with venous hypertension and an average age of 42 were given 60mg of purified gotu kola extract twice daily for six weeks, with another 20 given placebo and acting as a control.
- At the end of the trial circulation at rest (resting flux) was improved by 29% and small blood vessel function (venoarterioal response) was increased by 59%! Leg volume (puffiness) also decreased.
- In conclusion, the researchers stated that these "parameters were significant and clinically important at 6 weeks in the treatment group" and that "TTFCA improves microcirculation and leg volume in venous hypertension."
- Other studies on purified centella asiatica (one that contains 100% of asiatic acid, madecassic acid, asiaticoside and madecassoside) have reported similar results.
- Gotu kola / centella asiatica TTFCA extract is an ideal active against water retention and poor circulation, and it is used both in oral form (nutritional supplement) or as a circulation-aiding / anti-cellulite cream active ingredient.
- Source: Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry.
- Abstract: The aim of this prospective, randomized study was to demonstrate whether an oral preparation of TTFCA was effective in improving the microcirculation and edema (leg volume) in venous microangiopathy. Forty patients with venous hypertension were included. Treatment was prescribed for 6 weeks (tablets, 60 mg twice daily). Patients were randomized into a treatment and a placebo group. There were 20 patients in each group. In the treatment group the mean age was 42 (SD 7; M:F = 10:10); in the placebo group, the mean age was 40 (SD 9; M:F = 10:10). Tolerability and compliance were very good; there were no dropouts. At inclusion there were no differences between placebo and treatment group. After treatment there was a decrease in resting flux (29%) and an improvement (increase) in venoarteriolar response (52%); PO2 was increased (7.2%) and PCO2 decreased (9.6%). There was an important decrease in leg volume (66 mL decrease; 1.3% volume variation). The difference in flux, O2-CO2 and volume parameters were significant and clinically important at 6 weeks in the treatment group. In conclusion, TTFCA improves microcirculation and leg volume in venous hypertension. The effects of TTFCA are observed even in a limited sample of patients.
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