Centella asiatica / gotu kola extract found to boost collagen production in human collagen cells / fibroblasts

  • The medicinal herb centella asiatica / gotu kola is a south Asian plant known for centuries for it's connective tissue building and repair action
  • The most important components of centella asiatica are asiatic acid, madecassic acid and asiaticoside
  • In this study on human tissue cultures, a highly concentrated extract comprising solely the above natural chemicals was found to boost collagen synthesis, with increasing efficacy as the dose increased
  • Out of the three, asiatic acid was found to be the only component responsible for collagen synthesis stimulation. However, all three components increased proline in collagen tissue, showing a supportive collagen stimulation action (proline is the most important aminoacid in collagen).
  • Due to it's connective tissue growth and repair activity, gotu kola is ideal for use in skin anti-aging and anti-cellulite creams and supplements.
  • Source: Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica
  • Abstract: The drug "Titrated Extract from Centella asiatica" (TECA), used for its stimulating properties on the healing of wounds, is a mixture of 3 terpenes extracted from a tropical plant: asiatic acid (30%, w/w), madecassic acid (30%, w/w) and asiaticoside (40%, w/w). The effects of TECA and its individual components were checked on human foreskin fibroblast monolayer cultures. TECA increased the collagen synthesis in a dose-dependent fashion whereas a simultaneous decrease in the specific activity of neosynthesized collagen was observed. Asiatic acid was found to be the only component responsible for collagen synthesis stimulation. TECA and all three terpenes increased the intracellular free proline pool. This effect was independent of the stimulation of collagen synthesis.

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