Centella asiatica extract improves oedema, microcirculation, venous hypertension and capillary permeability in just two weeks

  • The botanical extract of centella asiatica / gotu kola is well-known for strengthening blood vessel walls. This as a results reduces leaky blood vessels (capillary premeability), high blood pressure in veins (venous hypertension) and oedema (puffiness / water retention), and improves circulation in small blood vessels (microcirculation) and tissue nourishment and oxygenation.
  • In a study involving people with mild and severe venous hypertension, it was shown that in just two weeks of treatment with purified gotu kola extract, there was a significant decrease of ankle and foot oedema in limbs with superficial and with deep venous incompetence.
  • Specifically it was shown that with 60mg of total triterpenic fraction of centella asiatica (TTFCA), taken twice daily, there was a significant reduction in both superficial and deep venous incompetence. "The improvement (decrease) of the abnormally increased capillary permeability was associated with a significant improvement of the microcirculation and symptoms", as the authors of the study stated.
  • The purified extract used of the study comprised 100% asiatic acid, madecassic acid, asiaticoside and madecassoside, i.e. all four important triterpenes found in centella asiatica. Unfortunately most nutritional supplements only contain 20% of those triterpenes and many anti-cellulite creams contain as little as 1%...
  • Centella asiatica extract has been proven time and again ideal in microcirculation enhancement and water retention reduction with both oral intake (as a nutritional supplement) and topical application (as an anti-cellulite cream ingredient).
  • Gotu kola, also known as hydrocotyle, asiatic pennywort and indian pennywort, is also traditionally used in teas, curries, juice drinks and other foods throughout south and southeast Asia, including Thailand, India, Sri Lanka and Vietnam - my local Thai shop in London, for example, sells fresh centella for use in foods :)
  • Source: Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA.
  • Abstract: The VSC (vacuum suction chamber) device, a new system to evaluate local capillary permeability, was used with laser Doppler flowmetry to study variations of permeability and of the microcirculation in 10 normal subjects; in 22 patients with moderate, superficial venous hypertension; and in 12 patients with postphlebitic limbs and severe venous hypertension. All these patients had distal (ankle and foot) oedema in the evening. After a first assessment these subjects were studied again after two weeks without treatment and after two weeks' treatment with total triterpenic fraction of centella asiatica (TTFCA), tablets, 60 mg, tid. The VSC produces a wheal on the skin of the perimalleolar region that disappears (in average) in less than sixty minutes in normal subjects. The disappearance time (DT) is greater in conditions of increased capillary filtration and permeability. The three groups of subjects (normal and those with superficial and severe venous hypertension) had significantly different, increasing disappearance time of the wheals at the first observation. There were no significant changes after two weeks' observation, but after 2 weeks' treatment with TTFCA, there was a significant decrease of DT both in limbs with superficial and with deep venous incompetence. The improvement (decrease) of the abnormally increased capillary permeability was associated with a significant improvement of the microcirculation and symptoms (studied by an analogue scale line). In conclusion this study showed a combined improvement of the microcirculation and capillary permeability after treatment with TTFCA and the possibility of using the VSC to evaluate the effects of drugs (or other treatment) on local capillary permeability in patients with venous hypertension.

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