Asiaticoside, from centella asiatica, helps wound healing by boosting the growth and function of fibroblasts / collagen cells

  • In this study asiaticoside, a natural chemical found in the herb gotu kola / centella asiatica, was found to boost the movement, adhesion and growth of collagen cells in wound sites, thereby accelerating wound healing
  • Due to their connective tissue healing / repair action, asiaticoside-rich centella asiatica extracts, are ideal candidates for anti-ageing, wound healing, stretch mark and anti-cellulite, under eye care creams.
  • Source: Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model
  • Abstract: Wound healing proceeds through a complex collaborative process involving many types of cells. Keratinocytes and fibroblasts of epidermal and dermal layers of the skin play prominent roles in this process. Asiaticoside, an active component of Centella asiatica, is known for beneficial effects on keloid and hypertrophic scar. However, the effects of this compound on normal human skin cells are not well known. Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. In a wound closure seeding model, asiaticoside increased migration rates of skin cells. By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.

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