Resveratrol leads to fat reduction and weight loss in animals and humans

  • Yet another study, published today, which shows that resveratrol boosts fat reduction - and is therefore ideal in the fight against cellulite
  • This study shows that resveratrol inhibits the growth of new fat cells (preadipocyte differentiation) and reduces the growth of mitochondria and fat storage in fat cells, leading to weight loss in animals and humans
  • Source: Resveratrol inhibits lipogenesis of 3T3-L1 and SGBS cells by inhibition of insulin signalling and mitochondrial mass increase
  • Abstract: Resveratrol is attracting much interest because of its potential to decrease body weight and increase life span, influencing liver and muscle function by increasing mitochondrial mass and energy expenditure. Even though resveratrol was already shown to reduce the adipose tissue mass in animal models, its effects on mitochondrial mass and network structure in adipocytes has not yet been studied. For this purpose, we investigated the effect of resveratrol on mitochondrial mass increase and remodelling during adipogenic differentiation of two in vitro models of adipocyte biology, the murine 3 T3-L1 cell line and the human SGBS cell strain. We confirm that resveratrol inhibits lipogenesis in differentiating adipocytes, both mouse and human. We further show that this is linked to inhibition of the normally observed mitochondrial mass increase and mitochondrial remodelling. At the molecular level, the anti-lipogenic effect of resveratrol seems to be mediated by a blunted expression increase and an inhibition of acetyl-CoA carboxylase (ACC). This is one of the consequences of an inhibited insulin-induced signalling via Akt, and maintained signalling via AMP-activated protein kinase. The anti-lipogenic effect of resveratrol is further modulated by expression levels of mitochondrial ATAD3, consistent with the emerging role of this protein as an important regulator of mitochondrial biogenesis and lipogenesis. Our data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signalling, mitochondrial biogenesis, and lipogenesis, and that resveratrol-induced reduction of mitochondrial biogenesis and lipid storage contribute to adipose tissue weight loss in animals and humans.

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