Resveratrol, pterostilbene and your skin

Antioxidant, anti-inflammatory, lipolytic and anti-ageing action

Resveratrol, found in black/purple grapes, red wine, blueberries and several other plants is one of the most well-known anti-ageing actives known today, and shares similar properties to its chemical analog, pterostilbene (also found in purple/black grapes, blueberries etc). Both have been found in numerous studies to be powerful antioxidants, anti-inflammatory and lipolytic actives and to reduce pigmentation, but above all they are known for their anti-ageing action, based on sirtuin (SIRT1) enhancement. For all those reasons, resveratrol and pterostilbene are of great importance as active ingredients in anti-ageing, anti-cellulite, leg wellness, skin lightening and under-eye creams [the Celluence® creams are the only leg wellness / cellulite creams in the world with high concentrations of 95%+ pure resveratrol and 95%+ pure pterostilbene, plus 38x other natural anti-cellulite actives].

 


 

Resveratrol & pterostilbene: The science

 

 

 

Chronic topical application of resveratrol accelerates wound healing...

...with improved epidermis, collagen deposition and improved vascularization of wound beds in young skin, due to stimulation of the AMPK pathway, the key mediator of wound healing. In aged skin, however, only metformin, a much stronger caloric restriction mimetic than resveratrol, was effective (in aged skin, AMPK pathway is inhibited, correlating with impaired vasculature and reduced healing ability)

[Source: Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application]
 

 

Resveratrol fights MITOCHONDRIAl-dysfunction related CONDITIONS...

...by protecting mitochondria from oxidative stress, by helping regulate their metabolism and biogenesis and by modulating cell apoptosis due to mitochondrial dysfunction [Source: Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease]

 

 

Resveratrol decreases lipid accumulation in adipocytes...

...by inhibiting PPAR-gamma, C/EBPs and their target genes (FAS, aP2, SCD-1, and LPL) [ISource: Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation]


  • Resveratrol, the phytochemical found in red wine, berries and other foods and considered responsible for their anti-ageing qualities, is known to trigger fat release from fat cells (lipolysis).
  • Resveratrol exerts both it's anti-ageing and it's anti-obesity effect by activating a protein called sirtuin (SIRT1). SIRT1 is a major target of anti-ageing strategies and now scientists have found that SIRT1 also stimulates fat release.
  • Sirtuin, and subsequently resveratrol, does that by: 
    • increasing another protein found in fat cells, called ATGL. ATGL (adipocyte trigluceride lipase) is well-known for it's stimulation of fat release
    • inhibiting a protein called PPAR-gamma, one of the most important triggers of fat accumulation
  • Now that the mechanism of action of resveratrol is clarified, applications of this natural, healthful chemical on anti-cellulite and anti-aging creams is further warranted.
  • Source: Sirtuin1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes
  • Abstract: To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 inhibitor nicotinamide (NAM) or a knockdown of Sirt1 by Sirt1-specific small interfering RNA (siRNA). The RES (50 μM) activated Sirt1 gene expression and increased ATGL gene expression and glycerol release (P < 0.01). The Sirt1 inhibitor NAM or knockdown with Sirt1 siRNA further proved that the ATGL mRNA abundances were decreased (P < 0.05) after inhibition with Sirt1 in adipocytes. Furthermore, we found the opposite Sirt1 regulation pattern for PPARγ to that of ATGL in adipocytes. In summary, Sirt1 regulates the transcriptional expression of ATGL in adipocytes, and PPARγ appears to have an important role in this process. These results add to our understanding of the role of Sirt1 in adipose mobilization.

Resveratrol fights ageing by boosting the activity of SIRT1

  • Resveratrol is a well-known anti-ageing and slimming natural compound and is one of the molecules associated with the anti-ageing effects of red wine (the "French paradox").
  • Now scientists in Hong Kong have found that resveratrol reduces stem cell decline and significantly extends life span in mice suffering from premature ageing (progeria), by helping bind a protein called Lamin A onto SIRT1, the "longevity" gene. By boosting the activity of the longevity gene, resveratrol helps fight ageing.
  • (Stem cells are "baby cells" that can be differentiated to any kind of cell in the body. Their number is reduced in ageing and resveratrol halts that decline, thereby boosting tissue regeneration and ageing. Common food sources of resveratrol include berries, grapes and red wine, among others.)
  • Resveratrol is an ideal anti-ageing and anti-cellulite cream active ingredient. It is more and more widely used as an anti-ageing supplement and is an ideal ingredient in anti-ageing creams.
  • In addition, resveratrol has been shown to halt the growth of new fat cells (adipogenesis), on it's own and when combined with other natural substances, such as the phytoestrogen genistein.
  • Therefore, resveratrol is also effective as an anti-cellulite cream active ingredient.
  • Source: http://www.ncbi.nlm.nih.gov/pubmed/23286696
  • Excerpt: "Resveratrol enhances the binding between SIRT1 and A-type lamins to increase its deacetylase activity. Resveratrol treatment rescues ASC decline, slows down body weight loss, improves trabecular bone structure and mineral density, and significantly extends the life span in Zmpste24/− mice."

resveratrol protects fat cells from inflammation, helps fight cellulite

  • Dietary phytochemicals called polyphenols are known potent antioxidants that protect body tissues from free radical damage and consequent inflammation.
  • Inflammation and oxidative damage are key components of cellulite, as well as diabetes and several other so-called civilisation diseases, such as heart disease and arthritis.
  • Recent research has now looked into 28 polyphenols (such as hesperidin, resveratrol, epigallocatechin gallate and curcumin) and concluded that those polyphenols protect fat cells from both oxidative damage and inflammation, by reducing inflammatory hormones, such as IL-6.
  • This practically means that orally taken polyphenols (either as foods or as supplements) can be used in the fight against fat tissue inflammation for the prevention of diabetes and cellulite.
  • Polyphenols may also be used with local application in the fight against cellulite as active ingredients in an anti-cellulite cream. Naturally, the more of those polyphenols are present in the cream the better results are to be expected, due to a synergistic effect of using multiple ingredients.
  • Source: Evaluation of antioxidant properties of major dietary polyphenols and their protective effect on 3T3-L1 preadipocytes and red blood cells exposed to oxidative stress
  • Abstract: "Obesity has been associated with a marked risk of metabolic diseases and requires therapeutic strategies. Changes in redox status with increased oxidative stress in adipose tissue have been linked with obesity-related disorders. Thus, the biological effect of antioxidants such as polyphenols is of high interest. We aimed to measure antioxidant capacities of 28 polyphenols representative of main dietary phenolic acids, flavonoids, stilbenes and curcuminoids. Then, 14 molecules were selected for the evaluation of their effect on 3T3-L1 preadipocytes and human red blood cells exposed to oxidative stress. Analysis of reducing and free radical-scavenging capacities of compounds revealed antioxidant properties related to their structure, with higher activities for flavonoids such as quercetin and epicatechin. Their effects on preadipocytes' viability also depended on their structure, dose and time of exposure. Interestingly, most of the compounds exhibited a protective effect on preadipocytes exposed to oxidative stress, by reversing H₂O₂-induced anti-proliferative action and reactive oxygen species production. Polyphenols also exerted an anti-inflammatory effect on preadipocytes exposed to H₂O₂ by reducing IL-6 secretion. Importantly, such antioxidant and anti-inflammatory effects were observed in co-exposition (polyphenol and prooxidant during 24 h) or pretreatment (polyphenol during 24 h, then prooxidant for 24 h) conditions. Moreover, compounds protected erythrocytes from AAPH radical-induced lysis. Finally, these results led to demonstrate that antioxidant and anti-inflammatory properties of polyphenols may depend on structure, dose, time of exposure and cell conditioning with oxidative stress. Such findings should be considered for a better understanding of polyphenols' benefits in strategies aiming to prevent obesity-related diseases."