Menthol, leg wellness & cellulite
Circulation / water retention, lipolysis, cellulite
Menthol, derived from mentha piperita (mint) or mentha arvensis (wild mint), has been found to help boost lipolysis and blood circulation (and thereby fight water retention). It also enhances the absorption of other active ingredients by the skin.
Menthol is therefore of great importance as active ingredient in anti-cellulite and leg wellness creams [the Celluence® cellulite creams with menthol (derived naturally from wild mint) combined with 39 other natural anti-cellulite actives].
4 ways Menthol
...helps boost circulation and lipolysis and fights water retention and cellulite
Dietary menthol-induced TRPM8 activation enhances WAT "browning" and ameliorates diet-induced obesity
Abstract: Beige adipocytes are a new type of recruitable brownish adipocytes, with highly mitochondrial membrane uncoupling protein 1 expression and thermogenesis. Beige adipocytes were found among white adipocytes, especially in subcutaneous white adipose tissue (sWAT). Therefore, beige adipocytes may be involved in the regulation of energy metabolism and fat deposition. Transient receptor potential melastatin 8 (TRPM8), a Ca(2+)-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the thermogenic function of brown adiposytes. However, the involvement of TRPM8 in the thermogenic function of WAT remains unexplored. Our data revealed that TRPM8 was expressed in mouse white adipocytes at mRNA, protein and functional levels. The mRNA expression of Trpm8 was significantly increased in the differentiated white adipocytes than pre-adipocytes. Moreover, activation of TRPM8 by menthol enhanced the expression of thermogenic genes in cultured white aidpocytes. And menthol-induced increases of the thermogenic genes in white adipocytes was inhibited by either KT5720 (a protein kinase A inhibitor) or BAPTA-AM. In addition, high fat diet (HFD)-induced obesity in mice was significantly recovered by co-treatment with menthol. Dietary menthol enhanced WAT "browning" and improved glucose metabolism in HFD-induced obesity mice as well. Therefore, we concluded that TRPM8 might be involved in WAT "browning" by increasing the expression levels of genes related to thermogenesis and energy metabolism. And dietary menthol could be a novel approach for combating human obesity and related metabolic diseases.