Medium chain triglycerides and your skin

Lipolysis and cellulite

Medium chain triglycerides (MCTs) comprise an oil naturally extracted from coconut (cocos nucifera) and has been found to inhibit fat accumulation / stimulate fat release from fat cells, and also to help absorption of other actives. Medium chain triglycerides are therefore of great importance as an active ingredient in anti-cellulite, anti-ageing and leg wellness creams.



MCT (Medium chain triglyceride) CREAM

The MCTs used for the Celluence® cellulite creams are of the highest quality and of 100% purity. We are pleased to include high quality medium chain triglycerides in our formulations, together with multiple other natural active ingredients, for maximum synergy and effectiveness. No other cellulite creams offer ALL the important anti-cellulite / leg wellness ingredients, in one package (learn how our creams differ from any other cellulite formulation.


Medium chain triglycerides (MCT): the science



Medium chain triglycerides (MCT) help reduce fat by initiating fat cell death

Comment: The fact that MCTs reduce fat by inducing adipocyte apoptosis makes them ideal as  - ideal as topical anti-cellulite cream actives

Source: Octanoate and decanoate induce apoptosis in 3T3-L1 adipocytes.

Abstract: The effect of octanoate and decanoate, respectively, eight- and 10-carbon medium-chain fatty acids (MCFAs), on apoptotic signaling in 3T3-L1 adipocytes was investigated. 3T3-L1 adipocytes were treated with various concentrations of octanoate or decanoate. Cell viability, apoptosis, and expression of apoptosis-related proteins were investigated. Results indicated that both octanoate and decanoate decreased viability, increased apoptosis, and increased reactive oxygen species production. Immunoblotting analysis showed an increase in the levels of cytoplasmic cytochrome c and cleaved poly(ADP-ribose) polymerase by octanoate and decanoate. Concomitantly, we observed that pro-caspase-3 was decreased, resulting in the induced accumulation of the cleaved form of caspase-3 by both octanoate and decanoate. In addition, both octanoate and decanoate increased the expression of pro-apoptotic Bax with an accompanied decrease of anti-apoptotic Bcl-2. These results show that octanoate and decanoate mediate adipocyte apoptosis via a caspase-dependent mitochondrial pathway in 3T3-L1 adipocytes. MCFAs thus decrease adipocyte number by initiating the apoptotic process in 3T3-L1 adipocytes.