Hesperidin, leg wellness & cellulite

Antioxidant protection, circulation enhancement, anti-ageing, cellulite

The flavonoid hesperidin (typically derived from citrus fruits, such as bitter orange) has been widely researched for decades and has been found in numerous studies to help boost circulation and thereby fight water retention. It is also a well-known antioxidant. 



Hesperidin is therefore of great importance as active ingredient in anti-cellulite, leg wellness and under-eye creams [the Celluence® cellulite / leg wellness creams are the only creams in the world with high concentrations of 95% pure, bioavailable hesperidin plus 39 other natural anti-cellulite actives. 





3+ ways Hesperidin

helps fight poor circulation / water retention, oxidative damage, skin, ageing and cellulite



3/ Hesperetin and hesperidin stimulate fat release and fat breakdown - ideal for cellulite reduction

Hesperetin was found to decrease the expression of resistin, adiponectin, aP2, LPL, PPAR-γ, and TNF-α in mesenchymal stem cells (hMSCs) and to significantly inhibit adipocyte differentiation and to increase the proapoptotic gene expression levels in preadipocytes (the water-insoluble flavonoid hesperidin (hesperetin 7-rutinoside) becomes hesperetin in the body).

Source: Hesperetin Inhibit Adipocyte Differentiation and Enhance Bax- and p21-Mediated Adipolysis in Human Mesenchymal Stem Cell Adipogenesis.



2/ Hesperidin protects fat cells from inflammation, helps fight cellulite

Inflammation and oxidative damage are key components of cellulite, as well as diabetes and several other so-called civilisation diseases, such as heart disease and arthritis. Recent research has now looked into 28 polyphenols (such as hesperidin, resveratrol, epigallocatechin gallate and curcumin) and concluded that those polyphenols protect fat cells from both oxidative damage and inflammation, by reducing inflammatory hormones, such as IL-6. This practically means that polyphenols (either as foods or as supplements) can be used in the fight against fat tissue inflammation for the prevention of diabetes and cellulite

[Source: Evaluation of antioxidant properties of major dietary polyphenols and their protective effect on 3T3-L1 preadipocytes and red blood cells exposed to oxidative stress]



1/ Review paper suggests hesperidin for the treatment of varicose veins

The loss of vascular integrity is associated with the pathogenesis of varicose veins. Several botanical extracts (horse chestnut/aesculus, butcher's broom/ruscus, gotu kola, flavonoids and pine bark) have been shown to improve microcirculation, capillary flow and vascular tone, and to strengthen the connective tissue of the perivascular amorphous substrate. Oral supplementation with may prevent time-consuming, painful, and expensive complications of varicose veins and hemorrhoids

[Source: Hemorrhoids and varicose veins: a review of treatment options]



Screening of potential anti-adipogenic effects of phenolic compounds showing different chemical structure in 3T3-L1 preadipocytes

This study was designed to analyze the anti-adipogenic effect of fifteen phenolic compounds from various chemical groups in 3T3-L1 pre-adipocytes. Cells were treated with 25 μM, 10 μM or 1 μM of apigenin, luteolin, catechin, epicatechin, epigallocatechin, genistein, daizein, naringenin, hesperidin, quercetin, kaempferol, resveratrol, vanillic acid, piceatannol and pterostilbene for 8 days. At 25 μM lipid accumulation was reduced by all the compounds, with the exception of catechin, epicatechin and epigallocatechin. At a dose of 10 μM apigenin, luteolin, naringenin, hesperidin, quercetin and kaempferol induced significant reductions, and at 1 μM only naringenin, hesperidin and quercetin were effective. The expression of c/ebpα was not. C/ebpβ was significantly reduced by genistein and kaempferol, pparγ by genistein and pterostilbene, srebp1c by luteolin, genistein, hesperidin, kaempferol, pterostilbene and vanillic acid, and lpl by kaempferol. In conclusion, the most effective phenolic compounds are naringenin, hesperidin and quercetin. Differences were found in terms of effects on the expression of genes involved in adipogenesis among the analyzed compounds.