Hesperidin, leg wellness & cellulite

The flavonoid hesperidin (typically derived from citrus fruits, such as bitter orange) has been widely researched for decades and has been found in numerous studies to help boost circulation and thereby fight water retention. It is also a well-known antioxidant. Hesperidin is therefore of great importance as active ingredient in anti-celluliteleg wellness and under-eye creams.



The hesperidin used for the Celluence® cellulite creams is of the highest quality and of >95% purity, i.e. it comprises more than 95% active molecule,  in a stabilised, fast-absorbing form. We are extremely proud to feature high quality, highly purified hesperidin in our formulations, together with multiple other natural active ingredients, for maximum synergy and effectiveness. No other cellulite creams offer ALL the important anti-cellulite / leg wellness ingredients, in one package (learn how our creams differ from any other cellulite formulation.


Hesperidin: The science


Hesperetin and hesperidin stimulate fat release and fat breakdown - ideal for cellulite reduction

  • Hesperetin (a type of flavonoid found in citrus fruits), has been found to fight fat accumulation of fat cells, as well as the growth of new fat cells, and encourages early cell death of fat cells.
  • In the body, stem cells can become preadipocytes ("baby" fat cells) and then mature adipocytes (fully grown fat cells), if they receive adipogenic (fat-growing) stimulation from the body. In the body such stimulation is typically provided by a fat-rich diet and inactivity and hormones such as estrogen (natural female hormones or the contraceptive pill), cortisol (stress) and insulin (high-carbohydrate diet).
  • For this study the researchers cultivated stem cells in an adipogenic medium designed to stimulate adipogenic conditions in the body. In such a medium, normally a stem cell will become pre-adipocyte and then adipocyte. However, hesperetin stopped stem cells from differentiating into adipocytes and actually encouraged the release of fat (lipolysis) and the premature death of pre-adipocytes (adipocyte apoptosis or adipolysis).
  • Due to it's anti-adipogenic, lipolytic and adipolytic effect, hesperetin, along with it's chemical cousin hesperidin, is ideal as an anti-cellulite cream ingredient.
  • (Note: The water-insoluble flavonoid hesperidin (hesperetin 7-rutinoside) becomes hesperetin in the body after digestion)
  • Source: Hesperetin Inhibit Adipocyte Differentiation and Enhance Bax- and p21-Mediated Adipolysis in Human Mesenchymal Stem Cell Adipogenesis.
  • Abstract: We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)-induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 13.2 μmol for 24 h and 89.4 ± 11.4 μmol in 48 h, whereas in preadipocytes was 87.6 ± 9.5 μmol and 72.4 ± 5.6 μmol in 24 h and 48 h, respectively. Hesperetin treatment (5, 10, and 20 μmol) to adipogenesis-induced hMSCs (Group 1) and preadipocytes (Group 2) resulted in a significantly (p < 0.05) increased lipolysis. The treatment with hesperetin decreased the expression of resistin, adiponectin, aP2, LPL, PPAR-γ, and TNF-α in Groups 1 and 2, whereas a significant increase was observed in Bcl, Bax, and p21 expression in Group 2 compared to untreated preadipocytes. hMSCs cultured in adipogenic medium along with hesperetin significantly inhibited adipocyte differentiation and increased the proapoptotic gene expression levels in preadipocyte. Our result indicates the antiadipogenic and adipolysis effects of hesperetin.

Hesperidin in food protects fat cells from inflammation, helps fight cellulite

  • Dietary phytochemicals called polyphenols are known potent antioxidants that protect body tissues from free radical damage and consequent inflammation.
  • Inflammation and oxidative damage are key components of cellulite, as well as diabetes and several other so-called civilisation diseases, such as heart disease and arthritis.
  • Recent research has now looked into 28 polyphenols (such as hesperidin, resveratrol, epigallocatechin gallate and curcumin) and concluded that those polyphenols protect fat cells from both oxidative damage and inflammation, by reducing inflammatory hormones, such as IL-6.
  • This practically means that orally taken polyphenols (either as foods or as supplements) can be used in the fight against fat tissue inflammation for the prevention of diabetes and cellulite.
  • Polyphenols may also be used with local application in the fight against cellulite as active ingredients in an anti-cellulite cream. Naturally, the more of those polyphenols are present in the cream the better results are to be expected, due to a synergistic effect of using multiple ingredients.
  • Source: Evaluation of antioxidant properties of major dietary polyphenols and their protective effect on 3T3-L1 preadipocytes and red blood cells exposed to oxidative stress
  • Abstract: "Obesity has been associated with a marked risk of metabolic diseases and requires therapeutic strategies. Changes in redox status with increased oxidative stress in adipose tissue have been linked with obesity-related disorders. Thus, the biological effect of antioxidants such as polyphenols is of high interest. We aimed to measure antioxidant capacities of 28 polyphenols representative of main dietary phenolic acids, flavonoids, stilbenes and curcuminoids. Then, 14 molecules were selected for the evaluation of their effect on 3T3-L1 preadipocytes and human red blood cells exposed to oxidative stress. Analysis of reducing and free radical-scavenging capacities of compounds revealed antioxidant properties related to their structure, with higher activities for flavonoids such as quercetin and epicatechin. Their effects on preadipocytes' viability also depended on their structure, dose and time of exposure. Interestingly, most of the compounds exhibited a protective effect on preadipocytes exposed to oxidative stress, by reversing H₂O₂-induced anti-proliferative action and reactive oxygen species production. Polyphenols also exerted an anti-inflammatory effect on preadipocytes exposed to H₂O₂ by reducing IL-6 secretion. Importantly, such antioxidant and anti-inflammatory effects were observed in co-exposition (polyphenol and prooxidant during 24 h) or pretreatment (polyphenol during 24 h, then prooxidant for 24 h) conditions. Moreover, compounds protected erythrocytes from AAPH radical-induced lysis. Finally, these results led to demonstrate that antioxidant and anti-inflammatory properties of polyphenols may depend on structure, dose, time of exposure and cell conditioning with oxidative stress. Such findings should be considered for a better understanding of polyphenols' benefits in strategies aiming to prevent obesity-related diseases."