Cellulite, anti-aging & centella asiatica

The combination of asiatic acid + madecassic acid + madecassoside + asiaticoside comprises probably the most important anti-cellulite active known today, due to it's multiple action on cellulite, circulation, stretch marks, skin firming and anti-ageing.

The combination is found in the centella asiatica (gotu kola) plant and is known as TECA (titrated extract of centella asiatica) or TTFCA (total triterpenic fraction of centella asiatica) and multiple research papers have found that it helps firm and repair skin and connective tissue, fight glycation, protect blood vessel wall integrity, boost circulation, fight fat tissue inflammation, stimulate fat release and inhibit pigmentation.



Gotu kola / centella asiatica creams

For all those reasons, centella asiatica / gotu kola is of great importance as an active ingredient in anti-cellulite, anti-ageing, leg wellness, skin brightening, skin firming, stretch mark and under-eye creams.

[LipoTherapeia offers Celluence®, the only leg wellness / cellulite creams in the world with high concentrations of 40x natural actives, including 95% pure TECA from madagascan centella asiatica]




Gotu kola / Centella asiatica: the science



The combination of centella asiatica, esculoside caffeine and L-carnitine maximise lipolysis by inhibiting alpha-2 adrenoreceptors

 In vitro tests demonstrated (a) a dramatic increase in the cyclic adenosine monophosphate (cAMP) content in human adipocytes, with a subsequent rise in the nonesterified fatty acids (NEFA) content of human adipocyte incubation medium, and (b) in vivo studies showed an actual potent slimming effect on human volunteers. Moreover, the combination antagonises the alpha(2)-adrenergic receptor that is known to reduce intracellular AMPc content and, subsequently, to down-regulate lipolysis.

[Source: An in vitro, ex vivo, and in vivo demonstration of the lipolytic effect of slimming liposomes: an unexpected alpha(2)-adrenergic antagonism]



gotu kola/centella asiatica can improve chronic venous insufficiency, lymphoedema and circulation impairment

Impaired skin microcirculation is a major contributing factor towards inflammation in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate predisposes to the formation of edema. Local lymphedema is a complication of CVI, often underdiagnosed. This paper, a review of randomised prospective controlled trials, shows that horse chestnut extract, flavonoids, total triterpenic fraction of centella asiatica and procyanidins reduce capillary filtration rate and improve levels of partial pressures of oxygen and carbon dioxide in skin and that combining with compression therapy may have some additive effects.

[Source: A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options]



Phlebitis ulcers heal with the aid of herbal cream consisting of gotu kola and other botanicals

This herbal compound, in combination with compression garments, significantly improved inflammation, healing time and pain in phlebitis, in relation to compression garments alone. Ivy extract in the cream contributed to pain reduction; horse chestnut, butcher's broom and grape seed extract reduced inflammation; and allantoin, gotu kola and hyaluronic acid aided sore healing. In patients who applied both the cream and the compression garment pain stopped in 72 hours, inflammation disappeared in one week, tissue swelling stopped in one week and healing was complete in 4 weeks.

[Source: Multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs]



Review paper suggests gotu kola for the treatment of varicose veins

The loss of vascular integrity is associated with the pathogenesis of varicose veins. Several botanical extracts (horse chestnut/aesculus, butcher's broom/ruscus, gotu kola, flavonoids and pine bark) have been shown to improve microcirculation, capillary flow and vascular tone, and to strengthen the connective tissue of the perivascular amorphous substrate. Oral supplementation with may prevent time-consuming, painful, and expensive complications of varicose veins and hemorrhoids

[Source: Hemorrhoids and varicose veins: a review of treatment options]