Dihydromyricetin, leg wellness & cellulite 

Dihydromyricetin (water soluble myricetin) is a flavonol found in myrica cerifera and several nuts and fruits.  Dihydromyricetin has been found to have lipolytic, anti-inflammatory, circulation-boosting and antioxidant action. Dihydromyricetin is therefore of great importance as an active ingredient in anti-cellulite, anti-ageing and leg wellness creams.



The dihydromyricetin used for the Celluence® cellulite creams is of the highest quality, >95% purity and encased in a patented formula for enhanced skin absorption. We are proud to feature a high quality, highly purified dihydromyricetin in our formulations, together with multiple other natural active ingredients, for maximum synergy and effectiveness. No other cellulite creams offer ALL the important anti-cellulite / leg wellness ingredients, in one package (learn how our creams differ from any other cellulite formulation).


Dihydromyricetin: The science



The antioxidant flavanol myricetin prevents wrinkle formation and skin ageing

  • Myricetin, a flavonol antioxidant, suppresses wrinkle formation and is an ideal anti-ageing cream ingredient
  • Scientists at Seoul National University have found that the major flavonoid myricetin prevents skin photo-ageing caused by ultraviolet light, the primary cause of skin ageing. This is in line with many naturally occurring phytochemicals that are known to delay the signs of ageing, such as resveratrol, EGCG etc.
  • Specifically, the study revealed that myricetin suppressed the action of a protein called matrix metalloproteinase-9 (MMP-9) after exposure to UV rays. Metalloproteinases are enzymes that break down skin proteins such as collagen and elastin and consequently cause skin ageing and/or skin looseness. Many antioxidants inhibit such enzymes, and myricetin, an antioxidant naturally occurring found in grapes, berries, wine, walnuts, fruits, vegetables and herbs, has been found to be one of them.
  • This property, along with it's antioxidant properties, makes myricetin an ideal anti-ageing cream ingredient.
  • Source: Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.
  • Abstract: Chronic exposure to solar ultraviolet (UV) light causes skin photoaging. Many studies have shown that naturally occurring phytochemicals have anti-photoaging effects, but their direct target molecule(s) and mechanism(s) remain unclear. We found that myricetin, a major flavonoid in berries and red wine, inhibited wrinkle formation in mouse skin induced by chronic UVB irradiation (0.18J/cm(2), 3 days/week for 15 weeks). Myricetin treatment reduced UVB-induced epidermal thickening of mouse skin and also suppressed UVB-induced matrix metalloproteinase-9 (MMP-9) protein expression and enzyme activity. Myricetin appeared to exert its anti-aging effects by suppressing UVB-induced Raf kinase activity and subsequent attenuation of UVB-induced phosphorylation of MEK and ERK in mouse skin. In vitro and in vivo pull-down assays revealed that myricetin bound with Raf in an ATP-noncompetitive manner. Overall, these results indicate that myricetin exerts potent anti-photoaging activity by regulating MMP-9 expression through the suppression of Raf kinase activity.