vitamin C, leg wellness & cellulite
Ascorbic acid (vitamin C) is one of the most important and most widely used anti-ageing actives. It is a key chemical in the body for collagen production, a very important antioxidant, helps protect blood vessels from damage and also exerts strong anti-pigmentation action. For all those reasons, ascorbic acid is of great importance as active ingredient in anti-ageing, anti-cellulite, leg wellness, skin firming, skin lightening and under-eye creams.
VITAMIN C CELLULITE creams, by Celluence®
The ascorbic acid used for the Celluence® cellulite creams is of the highest quality and of >95% purity and in a highly bioavailable form for enhanced absorption by the skin. We are proud to feature high quality, highly purified vitamin C in our formulations, together with multiple other natural active ingredients, for maximum synergy and effectiveness. No other cellulite creams offer ALL the important anti-cellulite / leg wellness ingredients, in one package (learn how our creams differ from any other cellulite formulation).
vitamin C: the science
Vitamin C in combination with radiofrequency markedly reduces adipose tissue
Vitamin C reduces adipogenesis, capacitive/resistive radiofrequency markedly reduces adipogenesis and actually leads to adipocyte apoptosis. The combination leads to severe adipocyte apoptosis (programmed cell death) [In-vitro study: Repressive effects of a capacitive-resistive electric transfer (CRet) hyperthermic apparatus combined with pro-vitamin C on intracellular lipid-droplets formation in adipocytes, https://www.ncbi.nlm.nih.gov/pubmed/23286696]
- Quercetin, one of the most versatile and healthful flavonoids, found in citrus fruits, onions and herbs like parsley, has been found in a study published this week to inhibit glycation and advanced glycation end-products (AGE)
- Glycation is a major cause of metabolic syndrome/diabetes, cardiovascular disease, skin ageing and overall body ageing and involves the damage of proteins by sugars
- Glycation is caused by the ingestion of excess carbohydrates, especially sugars. Heavily roasting food increases the amounts of glycation, while boiling produces no glycation.
- In this study, quercetin was compared to vitamin C, green tea extract, Padma Circosan (an ancient Tibetan multi-herbal formula) and, most especially, aminoguanidin (the standard with which anti-glycation agents are compared to).
- Quercetin was found to have the highest overall anti-glycation effect (60.5% reduction), higher than aminoguanidin itself, and to exert the highest high molecular weight AGE reduction (79.5% reduction)!
- Padma Circosan was found to inhibit lower molecular weight AGE more (74.9% reduction), while vitamin C had the best antioxidant effect.
- This study shows that glycation can be inhibited by widely available foods, supplements and anti-ageing cream actives, with the aim to fight whole body and skin ageing and deterioration cause by lifestyle factors.
- Source: Inhibitory actions of selected natural substances on formation of advanced glycation endproducts and advanced oxidation protein products.
- Abstract: BACKGROUND: Advanced glycation endproducts (AGE) and advanced oxidation protein products (AOPP) arise as a result of excessive glycation and oxidation processes of proteins in hyperglycemia and oxidative stress conditions respectively, both in vivo and in vitro. In vivo these processes are especially intensified in patients with diabetes, and the adverse effects of AGE and AOPP are particularly unfavorable for the pathogenesis and aggravate the biochemical disturbances and clinical complications of diabetes. Total AGE and AOPP (T-AGE and T-AOPP) are heterogeneous groups of compounds, and they can be divided into two main fractions: high- and low-molecular-weight, i.e. HMW-AGE and HMW-AOPP as well as LMW-AGE and LMW-AOPP. Therefore it is important to find natural substances that will prevent formation of total AGE and AOPP and their high- and low-molecular-weight fractions and thereby reduce their adverse effects on tissues and organs. METHOD: Selected natural substances and dietary supplements such as vitamin C, aminoguanidine, quercetin and green tea as well as the multicompound formulations Padma Circosan and Padma 28 were tested in an in vitro model using bovine serum albumin (BSA). Fluorescence of T-, HMW- and LMW-AGE and concentration of T-, HMW- and LMW-AOPP were measured after incubation with these substances. RESULTS: In the examined concentrations quercetin showed the greatest degree of inhibition for T-AGE (60.5 %) as well as for HMW-AGE (79.5 %), while in the case of LMW-AGE the greatest degree of glycation inhibition was shown by Padma Circosan (74.9 %). T-AOPP and HMW-AOPP were best inhibited by vitamin C (87.3 and 89.1 % respectively). The results obtained for LMW-AOPP are atypical, but the lowest concentration was observed in a sample with Padma 28. CONCLUSION: The results show that all tested natural compounds have inhibitory activity towards the formation of total and low- and high-molecular-weight forms of AGE and AOPP in vitro. That suggest a possible role in the prevention of diabetic complications, especially the multiherbal compound Padma preparations, which are especially effective in lowering the most dangerous, i.e. LMW fractions.
- Source: The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast
- Abstract: Centella asiatica (Linn.) Urban is well known in promoting wound healing and provides significant benefits in skin care and therapeutic products formulation. Glycolic acid and vitamins also play a role in the enhancement of collagen and fibronectin synthesis. Here, we evaluate the specific effect of Centella asiatica (CA), vitamins, glycolic acid and their mixture preparations to stimulate collagen and fibronectin synthesis in cultured human fibroblast cells. The fibroblast cells are incubated with CA, glycolic acid, vitamins and their mixture preparations for 48 h. The cell lysates were analyzed for protein content and collagen synthesis by direct binding enzyme immunoassay. The fibronectin of the cultured supernatant was measured by sandwich enzyme immunoassay. The results showed that CA, glycolic acid, vitamins A, E and C significantly stimulate collagen and fibronectin synthesis in the fibroblast. Addition of glycolic acid and vitamins to CA further increased the levels of collagen and fibronectin synthesis to 8.55 and 23.75 μg/100 μg, respectively. CA, glycolic acid, vitamins A, E, and C, and their mixtures demonstrated stimulatory effect on both extra-cellular matrix synthesis of collagen and fibronectin in in vitro studies on human foreskin fibroblasts, which is beneficial to skin care and therapeutic products formulation.
- A facial care regimen based on HUGE amounts of vitamin C (30%), retinol (0.5%), bakuchiol, CoQ10, vitamin E and herbal extract of ophiopogon japonica improved pigementation and overall facial condition in 12 weeks, as was found by a recently published study, but also increased skin dryness for 8 weeks
- However, the use of 30% (!) vitamin C is quite pointless in order to improve pigmentation, as the same result can be achieved by 1-2% curcumin or resveratrol, which in addition have more potent anti-ageing effects than vitamin C. To be honest, I really fail to understand why such mega doses need to be used...
- The use of multiple actives is commendable, however, and it is a nice departure from creams containing only a couple of actives. However, it would be nice if the formulators used the 28% of the excess vitamin C (2% is absolutely fine, more is not needed) to add other more advanced actives, for better synergy, better results and higher customer satisfaction.
- Retinol contributed to the anti-ageing effect but also to skin dryness
- Vitamin E, bakuchiol and CoQ10 also contributed to anti-ageing
- Source: An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin.
- Abstract: A 12-week open-label, single-center clinical usage trial was conducted to determine the effectiveness of a dual product regimen consisting of a 0.5% retinol treatment and an anti-aging moisturizer with 30% vitamin C in women with mild to moderate hyperpigmented and photodamaged facial skin. Clinical grading of several efficacy parameters, tolerability evaluations, subject self-assessment questionnaires, and digital photography were completed at baseline and at weeks 4, 8, and 12. A total of 44 women completed the study. Effective ingredients incorporated into the 0.5% retinol treatment included encapsulated retinol for a retinol concentration of 0.5%, bakuchiol, and Ophiopogon japonicus root extract. The anti-aging moisturizer with 30% vitamin C contained 30% vitamin C in the form of tetrahexyldecyl ascorbate (THD ascorbate), alpha-tocopheryl acetate (vitamin E) and ubiquinone (coenzyme Q10). The facial regimen produced a statistically significant decrease (improvement) in clinical grading scores for all parameters assessed at weeks 8 and 12 when compared with baseline scores. In addition, the majority of these parameters were improved at week 4. The test regimen was well-perceived by the subjects for various inquiries regarding facial skin condition, product efficacy, and product attributes. Several tolerability parameters were assessed with no statistically significant increase except for dryness. A statistically significant increase in clinical grading scores for dryness on the face occurred at weeks 4 and 8 when compared to baseline scores. The increase in dryness is expected when introducing a retinol product to a facial regimen and the dryness did not persist to the week 12 time point.
- In a double blind, cross over clinical trial, it was found that the combination of Ruscus aculeatus / (butcher's broom), hesperidin and ascorbic acid (vitamin C) improved vein function and venous disease in the lower legs (calves), especially after taking the supplement.
- Those three natural actives are well known for their vein / circulation supporting action and they are already used in anti-cellulite creams for this purpose.
- Source: Use of extract of Ruscus aculeatus in venous disease in the lower limbs
- Abstract: The effectiveness and tolerability of a venotropic drug (RAES) composed of an extract of Ruscus aculeatus (16.5 mg), hesperidin (75 mg) and ascorbic acid (50 mg) were evaluated in 40 patients (30 female, 10 male) aged between 28 and 74 years, suffering from chronic phlebopathy of the lower limbs. The cross-over, double-blind trial involved two periods of treatment of 2 months with the drug (2 capsules, 3 times/day) or with placebo, and an interim period of 15 days for wash-out. An overall tendency for improvement occurred that was more distinct during the periods of treatment with the drug. In fact, symptoms and plethysmographic parameters (in particular MVIV 40 and 60) immediately changed significantly in correspondence with the administration of RAES. The biological and clinical tolerability were excellent.
- The combination of ruscus aculeatus, vitamin C (ascorbic acid) and hesperidin has been found to improve capillary structure and chronic venous hypertension, and for these reasons it is ideal for inclusion in anti-cellulite / leg wellness creams.
- Source 1: Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD).
- Abstract 1: OBJECTIVES: To evaluate changes on cutaneous microangiopathy in chronic venous disorder (CVD) after use of Cirkan [venotonic drug containing Ruscus aculeatus (plant extract), hesperidine methylchalcone (flavonoid) and vitamin C], elastic compression stockings (ECS) or no treatment for four weeks. PATIENTS AND METHODS: Fifty-five female patients (85 legs), 25 to 57 years, with at least one limb classified as C2,s or C2,3,s (CEAP classification), were allocated consecutively, according to entrance order, in these three groups. Ten healthy women age-matched were also investigated. Using orthogonal polarization spectral technique (noninvasive method), measurements of functional capillary density (FCD, number of capillaries with flowing red blood cells/mm(2)), capillary morphology (CM, % of abnormal capillaries/mm(2)) and diameters (mum) of dermal papilla (DDP), capillary bulk (DCB) and capillary limb (CD) were obtained on the medial perimalleolar region and later analyzed using CapImage software. RESULTS AND CONCLUSIONS: CVD patients showed significant changes on CD and CM compared to healthy subjects in agreement with our previous findings (J Vasc Surg 43:1037-1044, 2006). On Cirkan-treated patients, after 4 weeks, CD decreased on both limbs and CM improved on the left one, suggesting an amelioration of the chronic venous hypertension. No significant changes could be detected on other patient groups. These results confirm the existence of microcirculatory dysfunction in early stages of CVD, probably due to post-capillary hypertension, and further support the venotonic action of Cirkan.
- Source 2: Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients.
- Abstract AIM: Clinical and capillaroscopic evaluation of an association of Ruscus aculeatus, hesperidin methylchalcone (HMC) and ascorbic acid in chronic venous insufficiency METHODS: A prospective, multicenter and open clinical study. Chronic venous insufficiency patients were studied using clinical, etiological, anatomical, physiological classification (CEAP) symptom scale. Symptomatology, CEAP scale, and baseline, 2-, 4-, 6- and 8-week skin capillaroscopy were assessed. Treatment consisted of two capsules per day of Ruscus aculeatus 150 mg/HMC 150 mg/ascorbic acid 100 mg during 8 weeks. RESULTS: A total of 124 patients were studied, 109 female (89.28%), with a mean age of 52.5 (33-80+9.8). Initial intense reports were 79% pain, 85% heaviness, 74% cramps, 82% edema, decreasing to 20%, 12%, 8% and 14%, respectively, within two weeks, and symptomatology being absent at the end of treatment. Capillaroscopy changes at treatment completion were: 98% to 20% inter-capillary fluid decrease; 80% to 20% efferent loop thickening; 5% to 2% peri-capillary bed, and 5% to 4% mega-capillaries. CONCLUSION: Severe symptom decrease started from the second week until there were no symptoms at the end of treatment. It is the first time morphologic changes were observed in chronic venous insufficiency through capillaroscopy following a pharmacological intervention. Capillary-level effect was proportional to symptom decrease. Improvement was seen from the second week of treatment.
- In a study comparing patient satisfaction of different therapies of advanced stage chronic venous disease it was found that of the 780 patients studied, and after six weeks of treatment, 71.3% were satisfied after surgical intervention; 51.4% with a natural vasoactive drug (supplement) consisting of ruscus aculeatus (butcher's broom), HMC (hesperidin) and ascorbic acid (vitamin C); and 43% with compression therapy (pressotherapy / bandaging).
- In the drug/supplement group, "out of 377 patients with active venous ulcers smaller than 200 cm2, 18% have been cured, and 66.6% have improved during 6-week period of observation!
- The researchers concluded that effects exerted on veins, capillaries and lymphatic vessels by the vasoactive supplement/drug explain the positive results observed in this study.
- All three components of the drug, i.e. ruscus, ascorbic acid and hesperidin are well researched and widely established for their natural and safe vein / circulation / lymphatic drainage supporting action, and they are valuable ingredients, taken either orally (supplements) or locally (creams) in the fight against venous insufficiency, water retention, poor circulation and cellulite.
- Given that new, more advanced vasoactive supplements exist today, if those newer, more advanced products were used, most probably an even higher number of customer satisfaction would have been recorded.
- Source: Patients' satisfaction with therapy methods of advanced chronic venous disease.
- Abstract AIM: To assess patients' satisfaction from the therapy of advanced chronic venous disorders (CVD) in everyday clinical practice in Poland, and to compare the efficacy of various venoactive drugs (VADs) in venous ulcers healing process. METHODS: 780 unselected adult patients with active (N=441) or healed (N=339) venous ulcers participated in the non-interventional observational 6-week study. RESULTS: Compression therapy and VADs were utilized by 81.5% and 89.2% of patients respectively. 31.2% of all patients underwent surgical procedures for vein incompetence, 61.3% were satisfied with surgical methods, 43% with compression therapy, and 32.6% with VADs - with highest rate of satisfied patients in the group taking Ruscus aculeatus and HMC and ascorbic acid (51.4%). Of 377 patients with active venous ulcers smaller than 200 cm2, adherent to VADs, 18.0% have been cured, and 66.6% have improved during 6-week period of observation. Multiple logistic regression analysis revealed that the compression therapy [OR=2.74], the size of ulcer ≤ 10 cm2 [OR=2.70] were increasing the change of ulcer healing. No VADs was better than another in the healing process. CONCLUSIONS: 1) Compression therapy and VADs are highly utilized by patients with advanced CVD. 2) Patients are more satisfied with surgical than conservative treatment of advanced CVD. 3) More than half of the patients with the advanced stage CVD taking Ruscus aculeatus and HMC and ascorbic acid is satisfied with the obtained improvement. 4) Ruscus aculeatus and HMC and ascorbic acid is similarly effective as other frequently used VADs in venous ulcer healing. 5. Ruscus aculeatus and HMC and ascorbic acid exerting effects on veins, capillaries and lymphatic vessels may explain the positive results observed in this study.
- The combination of Ruscus aculeatus (butcher's broom), hesperidin methyl chalcone (HMC) and ascorbic acid has been tested before on patients with lower limb chronic venous insufficiency and was found effective in reducing water retention and improving vein tone.
- In this study patients with chronic venous disorders (CVD) were assessed after 12 weeks of taking a nutritional supplement comprising of the three actives mentioned above.
- At the conclusion of the study it was found that "all clinical symptoms significantly improved with treatment, especially for patients with higher body mass index and heavier pathology. Ankle circumference, which reveals the extension of water retention decreased over time, gradually decreased and both the physical and psychological dimensions of quality of life significantly increased over time and improved in all types of patients.
- The researchers concluded that" "A 12-week treatment with ruscus aculeatus, HMC and ascorbic acid showed a significant decrease in clinical symptoms and a significant improvement in the quality of life of patients with chronic venous disorder".
- The results are unsurprising, given the well-studied circulation-enhancing and blood vessel-protecting effects these separate actives have on their own.
- Given that poor circulation is an important aspect of cellulite, this combination is also ideal for the treatment of cellulite, both when taken orally (food supplement) or applied locally (cellulite cream). Other active ingredients, in addition to the above three, would offer enhanced synergy and maximum results.
- Source: Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl chalcone and ascorbic acid (quality study).
- Abstract: AIM: The present study assessed the effect of Ruscus aculeatus, hesperidin methyl-chalcone and ascorbic acid (HMC-AA), in the treatment of chronic venous disorders (CVD) in Latin American patients. METHODS: This study is an observational, single arm, multicentric and prospective trial. Patients suffering from CVD and belonging to C0s-C3 Clinical Etiological Anatomical and Physiopathological (CEAP) classes were included. Patient profiles, risk factors, clinical symptomatology and quality of life (QoL) assessed by SF-12 and CIVIQ questionnaires were evaluated at inclusion and after 12-week treatment. RESULTS: The main factors influencing the previous management of patients were age, gender, body mass index (BMI), familial history, physical activity, exposure to heat, heavy loads lifting, profession and clinical characteristics. All clinical symptoms significantly improved with treatment and, as BMI and CEAP classes increased. Ankle circumferences decreased over time, correlating with BMI and CEAP classes. The physical and psychological dimensions of the SF-12 score significantly increased over time and improved within each CEAP class. The CIVIQ score significantly improved over time, correlating with age and CEAP classes. CONCLUSION: A 12-week treatment with Ruscus aculeatus HMC-AA showed a significant decrease in the clinical symptoms and a significant improvement in the QoL of patients with CVD.
- Ruscus aculeaus (butcher's broom) extract is well known for it's action on circulation improvement and chronic vein insufficiency. The flavonoid hesperidin and Vitamin C are also well established vein toning natural chemicals.
- In a study asessing the effectiveness of the combination of these three venotonic chemicals, it was found that patients with chronic venous insufficiency that took 2 capsules a day for 60 days, experienced "significant decrease and regression of clinical symptoms and a reduction in lower limb circumference measured at the ankle were observed."
- Ruscogenin and neoruscogenin, found in butcher's broom extract, are important actives against poor circulation and, as expected, work better in combination with other circulation-enhancing actives. Local application, in the form of microcirculation-boosting or anti-cellulite creams and food supplements is warranted.
- Source: A Study of the Efficacy and Tolerability of a Preparation Containing Ruscus aculeatus in the Treatment of Chronic Venous Insufficiency of the Lower Limbs
- Abstract: Objective: The objective of the study was to assess the efficacy and tolerability of an extract of Ruscus aculeatus combined with hesperidin methyl chalcone and ascorbic acid (Cyclo 3 Fort®) in the treatment of uncomplicated chronic venous insufficiency. Design and Methods: A randomised, double-blind, placebo-controlled study was conducted in 60 patients with uncomplicated chronic venous insufficiency. The patients received two daily capsules of a Ruscus extract combination formulation or placebo for a period of 60 days. Results: During the period of treatment with the Ruscus extract combination formulation, a significant decrease and regression of clinical symptoms and a reduction in lower limb circumference measured at the ankle were observed. The overall assessment of efficacy in the 30 patients receiving the active drug combination showed an excellent result in 15 patients, good in 13 and moderate in two. Of the 30 patients receiving placebo, the results were excellent in four, good in 17, moderate in eight and insufficient in one. Tolerability was considered excellent in 23 cases, good in five and poor in two. Conclusion: It was concluded that Ruscus extract combined with hesperidin methyl chalcone and ascorbic acid is effective and well tolerated in the treatment of patients with uncomplicated venous-lymphatic insufficiency of the lower limbs.